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Occupational Exposures and Subclinic...
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Sack, Coralynn.
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Occupational Exposures and Subclinical Interstitial Lung Disease: The Mesa (Multi-Ethnic Study of Atherosclerosis) Air-Lung Study.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Occupational Exposures and Subclinical Interstitial Lung Disease: The Mesa (Multi-Ethnic Study of Atherosclerosis) Air-Lung Study./
作者:
Sack, Coralynn.
出版者:
Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:
46 p.
附註:
Source: Masters Abstracts International, Volume: 57-05.
Contained By:
Masters Abstracts International57-05(E).
標題:
Epidemiology. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10234542
ISBN:
9780355849318
Occupational Exposures and Subclinical Interstitial Lung Disease: The Mesa (Multi-Ethnic Study of Atherosclerosis) Air-Lung Study.
Sack, Coralynn.
Occupational Exposures and Subclinical Interstitial Lung Disease: The Mesa (Multi-Ethnic Study of Atherosclerosis) Air-Lung Study.
- Ann Arbor : ProQuest Dissertations & Theses, 2018 - 46 p.
Source: Masters Abstracts International, Volume: 57-05.
Thesis (Master's)--University of Washington, 2018.
Rationale: The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied.
ISBN: 9780355849318Subjects--Topical Terms:
568544
Epidemiology.
Occupational Exposures and Subclinical Interstitial Lung Disease: The Mesa (Multi-Ethnic Study of Atherosclerosis) Air-Lung Study.
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Rationale: The impact of a broad range of occupational exposures on subclinical interstitial lung disease (ILD) has not been studied.
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Objectives: To determine whether occupational exposures to vapors, gas, dust, and fumes (VGDF) are associated with high-attenuation areas (HAAs) and interstitial lung abnormalities (ILAs4), which are quantitative and qualitative computed tomography (CT)--based measurements of subclinical ILD, respectively.
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Methods: We performed analyses of participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a population-based cohort aged 45--84 years at recruitment. HAA was measured at baseline and on serial cardiac CT scans in 5,702 participants. ILA was ascertained in a subset of 2,312 participants who underwent full-lung CT scanning at 10-year follow-up. Occupational exposures were assessed by self-reported VGDF exposure and by job-exposure matrix (JEM). Linear mixed models and logistic regression were used to determine whether occupational exposures were associated with log-transformed HAA and ILA. Models were adjusted for age, sex, race/ethnicity, education, employment status, tobacco use, and scanner technology.
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Results: Each JEM score increment in VGDF exposure was associated with 2.64% greater HAA (95% confidence interval [CI], 1.23--4.19%). Self-reported vapors/gas exposure was associated with an increased odds of ILA among those currently employed (1.76-fold; 95% CI, 1.09--2.84) and those less than 65 years old (1.97-fold; 95% CI, 1.16--3.35). There was no consistent evidence that occupational exposures were associated with progression of HAA over the follow-up period.
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Conclusions: JEM-assigned and self-reported exposures to VGDF were associated with measurements of subclinical ILD in community-dwelling adults.
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