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Approaching magnetic field effects i...

Canfield, Jeffrey Michael.

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Approaching magnetic field effects in biology using the radical pair mechanism.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Approaching magnetic field effects in biology using the radical pair mechanism./
作者:	Canfield, Jeffrey Michael.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 1997,
面頁冊數:	212 p.
附註:	Source: Dissertations Abstracts International, Volume: 61-05, Section: B.
Contained By:	Dissertations Abstracts International61-05B.
標題:	Molecules. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9812544
ISBN:	9780591633825

Approaching magnetic field effects in biology using the radical pair mechanism.
Canfield, Jeffrey Michael.

Approaching magnetic field effects in biology using the radical pair mechanism. - Ann Arbor : ProQuest Dissertations & Theses, 1997 - 212 p.

Source: Dissertations Abstracts International, Volume: 61-05, Section: B.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1997.

This item must not be sold to any third party vendors.

The overall goal of this thesis has been to explain any of the reported magnetic field effects in biology (magnetic orientation of many species and/or health effects, such as cancer, due to man-made electromagnetic fields) using the radical pair mechanism, a quantum mechanical mechanism known for over 20 years that lets singlet-to-triplet yields (which can be related to reaction rates) of radical pair reactions depend on applied magnetic fields. This goal seems reasonable considering the known roles of many biological free radicals in cancer, disease, aging, development, and cellular signaling, the constant reminders in the media to take anti-oxidant vitamins to protect against certain deleterious free radicals, and the success of the radical pair mechanism in explaining magnetic field effects in photosynthetic reaction centers. To approach the above goal, this thesis develops several methods (using perturbation theory and other techniques in the Schrodinger and Liouville formalisms) for calculating singlet-to-triplet yields in combinations of steady and oscillating fields (some of these algorithms are more versatile or efficient while others give more insight, and all serve as cross-checks on each other) and uses these tools to explore and explain a number of interesting phenomena such as yields sensitive to the magnitude and orientation of earth-strength (0.5 G) steady fields as well as the magnitude, orientation, and frequency of very weak (7 mG or less) oscillating fields. In particular, this thesis examines such effects in several coenzyme $\\rm B\\sb $ systems, systems long studied by EPR (Electron Paramagnetic Resonance, the chief method for determining the spin Hamiltonians, spin relaxation rates, and other parameters needed for calculations) in which organometallic cobalt-carbon bonds are often cleaved homolytically to form radical pairs. Among the $\\rm B\\sb $-dependent enzymes are ribonucleotide reductase (which converts RNA to DNA nucleotides), methyl malonyl CoA mutase (which controls the metabolism of certain fatty acids in mammals), and methionine synthase (which in mammals is used to regenerate active methyl groups on S-adenosyl methionine, which is involved in DNA methylation, melatonin and epinephrine synthesis, myelination, and methylation of chemotaxis proteins).* ftn*Originally published in DAI Vol. 58, No. 10. Reprinted here with revised abstract.

ISBN: 9780591633825Subjects--Topical Terms:

592642
Molecules.

Approaching magnetic field effects in biology using the radical pair mechanism.
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520 $a The overall goal of this thesis has been to explain any of the reported magnetic field effects in biology (magnetic orientation of many species and/or health effects, such as cancer, due to man-made electromagnetic fields) using the radical pair mechanism, a quantum mechanical mechanism known for over 20 years that lets singlet-to-triplet yields (which can be related to reaction rates) of radical pair reactions depend on applied magnetic fields. This goal seems reasonable considering the known roles of many biological free radicals in cancer, disease, aging, development, and cellular signaling, the constant reminders in the media to take anti-oxidant vitamins to protect against certain deleterious free radicals, and the success of the radical pair mechanism in explaining magnetic field effects in photosynthetic reaction centers. To approach the above goal, this thesis develops several methods (using perturbation theory and other techniques in the Schrodinger and Liouville formalisms) for calculating singlet-to-triplet yields in combinations of steady and oscillating fields (some of these algorithms are more versatile or efficient while others give more insight, and all serve as cross-checks on each other) and uses these tools to explore and explain a number of interesting phenomena such as yields sensitive to the magnitude and orientation of earth-strength (0.5 G) steady fields as well as the magnitude, orientation, and frequency of very weak (7 mG or less) oscillating fields. In particular, this thesis examines such effects in several coenzyme $\\rm B\\sb $ systems, systems long studied by EPR (Electron Paramagnetic Resonance, the chief method for determining the spin Hamiltonians, spin relaxation rates, and other parameters needed for calculations) in which organometallic cobalt-carbon bonds are often cleaved homolytically to form radical pairs. Among the $\\rm B\\sb $-dependent enzymes are ribonucleotide reductase (which converts RNA to DNA nucleotides), methyl malonyl CoA mutase (which controls the metabolism of certain fatty acids in mammals), and methionine synthase (which in mammals is used to regenerate active methyl groups on S-adenosyl methionine, which is involved in DNA methylation, melatonin and epinephrine synthesis, myelination, and methylation of chemotaxis proteins).* ftn*Originally published in DAI Vol. 58, No. 10. Reprinted here with revised abstract.
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