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Dose-finding designs for early-phase...

Daimon, Takashi.

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Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Dose-finding designs for early-phase cancer clinical trials/ by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui.
Reminder of title:	a brief guidebook to theory and practice /
Author:	Daimon, Takashi.
other author:	Hirakawa, Akihiro.
Published:	Tokyo :Springer Japan : : 2019.,
Description:	xv, 133 p. :ill., digital ;24 cm.
[NT 15003449]:	1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs.
Contained By:	Springer eBooks
Subject:	Antineoplastic agents. -
Online resource:	https://doi.org/10.1007/978-4-431-55585-8
ISBN:	9784431555858

Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /
Daimon, Takashi.

Dose-finding designs for early-phase cancer clinical trialsa brief guidebook to theory and practice /[electronic resource] :by Takashi Daimon, Akihiro Hirakawa, Shigeyuki Matsui. - Tokyo :Springer Japan :2019. - xv, 133 p. :ill., digital ;24 cm. - JSS research series in statistics,2364-0057. - JSS research series in statistics..

1. Introduction -- 2. Dose Finding in Early Phase Clinical Trials -- 3. Rule -- Based Designs -- 4. Continual Reassessment Method Designs -- 5. Escalation with Overdose Control Designs -- 6. Decision -- Theoretic Designs -- 7. Complex Designs.

This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.

ISBN: 9784431555858

Standard No.: 10.1007/978-4-431-55585-8doiSubjects--Topical Terms:

795427
Antineoplastic agents.

LC Class. No.: RC271.C5 / D356 2019

Dewey Class. No.: 615.798

Dose-finding designs for early-phase cancer clinical trials = a brief guidebook to theory and practice /
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520 $a This book provides a comprehensive introduction to statistical methods for designing early phase dose-finding clinical trials. It will serve as a textbook or handbook for graduate students and practitioners in biostatistics and clinical investigators who are involved in designing, conducting, monitoring, and analyzing dose-finding trials. The book will also provide an overview of advanced topics and discussions in this field for the benefit of researchers in biostatistics and statistical science. Beginning with backgrounds and fundamental notions on dose finding in early phase clinical trials, the book then provides traditional and recent dose-finding designs of phase I trials for, e.g., cytotoxic agents in oncology, to evaluate toxicity outcome. Included are rule-based and model-based designs, such as 3 + 3 designs, accelerated titration designs, toxicity probability interval designs, continual reassessment method and related designs, and escalation overdose control designs. This book also covers more complex and updated dose-finding designs of phase I-II and I/II trials for cytotoxic agents, and cytostatic agents, focusing on both toxicity and efficacy outcomes, such as designs with covariates and drug combinations, maximum tolerated dose-schedule finding designs, and so on.
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