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Applications of Synthetic Microchann...

Hinkle, Thomas Preston.

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Applications of Synthetic Microchannel and Nanopore Systems.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Applications of Synthetic Microchannel and Nanopore Systems./
作者:	Hinkle, Thomas Preston.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	154 p.
附註:	Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.
Contained By:	Dissertation Abstracts International79-04B(E).
標題:	Biophysics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10634207
ISBN:	9780355413847

Applications of Synthetic Microchannel and Nanopore Systems.
Hinkle, Thomas Preston.

Applications of Synthetic Microchannel and Nanopore Systems. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 154 p.

Source: Dissertation Abstracts International, Volume: 79-04(E), Section: B.

Thesis (Ph.D.)--University of California, Irvine, 2017.

This thesis describes research conducted on the physics and applications of micro- and nanoscale ion-conducting channels. Making use of the nanoscale physics that takes place in the vicinity of charged surfaces, there is the possibility that nanopores, holes on the order of 1 nm in size, could be used to make complex integrated ionic circuits. For inspiration on what such circuits could achieve we only need to look to biology systems, immensely complex machines that at their most basic level require precise control of ions and intercellular electric potentials to function. In order to contribute to the ever expanding field of nanopore research, we engineered novel hybrid insulator-conductor nanopores that behave analagously to ionic diodes, which allow passage of current flow in one direction but severely limit the current in the opposite direction. The experiments revealed that surface polarization of the conducting material can induce the formation of an electrical double layer in the same way static surface charges can. Furthermore, we showed that the hybrid device behaved similar to an ionic diode, and could see potential use as a standard rectifying element in ionic circuits.

ISBN: 9780355413847Subjects--Topical Terms:

518360
Biophysics.

Applications of Synthetic Microchannel and Nanopore Systems.
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520 $a Another application based on ion conducting channels is resistive pulse sensing, a single particle detection and characterization method. We present three main experiments that expand the capacity of resistive pulse sensing for particle characterization. First, we demonstrate how resistive pulse sensing in pores with longitudinal irregularities can be used to measure the lengths of individual nanoparticles. Then, we describe an entirely new hybrid approach to resistive pulse sensing, whereby the electrical measurements are combined with simultaneous optical imaging. The hybrid method allows for validation of the resistive pulse signals and will greatly contribute to their interpretability. We present experiments that explore some of the possibilities of the hybrid method. Then, building off the hybrid method we present experiments performed to measure single particle deformability with resistive pulse sensing. Using a novel microfluidic channel design, we were able to reproducibily induce bidirectional deformation of cells. We describe how these deformations could be detected with the resistive pulse signal alone, paving the way for resistive pulse sensing based cell deformability cytometers.
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