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Regulation of Transcriptional Machin...

Bruning, John.

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Regulation of Transcriptional Machinery and Its Relationship to Disease.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Regulation of Transcriptional Machinery and Its Relationship to Disease./
作者:	Bruning, John.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
面頁冊數:	178 p.
附註:	Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.
Contained By:	Dissertation Abstracts International79-01B(E).
標題:	Biophysics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10288062
ISBN:	9780355143140

Regulation of Transcriptional Machinery and Its Relationship to Disease.
Bruning, John.

Regulation of Transcriptional Machinery and Its Relationship to Disease. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 178 p.

Source: Dissertation Abstracts International, Volume: 79-01(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2017.

Transcription is the process in which our genetic information in the form of DNA is first utilized to create the machinery, structural integrity, and regulatory components that allows for cells to simply survive. While there are many, many, many regulatory modes and mechanisms that govern processes from enzyme catalysis to cell differentiation (and everything in between), the regulation of transcription is the initial decision to 'put the players on the pitch.' Transcriptional regulation is immensely complex, as it rightfully should be, as it is required for both simple procedures, for example simply increasing the mRNA copy number of a single species in response to a cellular cue, to intricately coordinated events such as decisions regarding cell fate. Transcription factors are the protein components that interplay between environmental cues and gene expression. In particular, nuclear receptors are ligand dependent transcription factors that are modulated by a small molecule ligand which provides information about a particular metabolic pathway. The focus of my research has been a biochemical and structural understanding of how this subset of transcriptional machinery is implicated in the etiology of disease.

ISBN: 9780355143140Subjects--Topical Terms:

518360
Biophysics.

Regulation of Transcriptional Machinery and Its Relationship to Disease.
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