東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Towards the Total Synthesis of the X...

Trotta, Adam Howell.

FindBook

Google Book

Amazon

博客來

Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B./
作者:	Trotta, Adam Howell.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2018,
面頁冊數:	312 p.
附註:	Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
Contained By:	Dissertation Abstracts International79-03B(E).
標題:	Organic chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10635024
ISBN:	9780355501872

Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B.
Trotta, Adam Howell.

Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B. - Ann Arbor : ProQuest Dissertations & Theses, 2018 - 312 p.

Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.

Thesis (Ph.D.)--Weill Medical College of Cornell University, 2018.

The xiamycin family of indolosesquiterpenes comprises bioactive compounds isolated from several strains of Streptomyces. Several dimeric family members have shown strong activity against several strains of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus (VRE). These promising initial results, coupled with the limited production of these compounds from their natural sources, prompted the design of a unified synthetic strategy capable of producing several family members from a common synthetic intermediate.

ISBN: 9780355501872Subjects--Topical Terms:

523952
Organic chemistry.

Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B.
LDR:02474nmm a2200325 4500 001 2163298
005 20181022132248.5
008 190424s2018 ||||||||||||||||| ||eng d
020 $a 9780355501872
035 $a (MiAaPQ)AAI10635024
035 $a (MiAaPQ)med.cornell:10330
035 $a AAI10635024
040 $a MiAaPQ $c MiAaPQ
100 1 $a Trotta, Adam Howell. $3 3351311
245 1 0 $a Towards the Total Synthesis of the Xiamycin Family of Indolosesquiterpenes: Synthesis Of Oridamycins A and B.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2018
300 $a 312 p.
500 $a Source: Dissertation Abstracts International, Volume: 79-03(E), Section: B.
500 $a Advisers: Samuel J. Danishefsky; Derek S. Tan.
502 $a Thesis (Ph.D.)--Weill Medical College of Cornell University, 2018.
520 $a The xiamycin family of indolosesquiterpenes comprises bioactive compounds isolated from several strains of Streptomyces. Several dimeric family members have shown strong activity against several strains of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant Enterococcus (VRE). These promising initial results, coupled with the limited production of these compounds from their natural sources, prompted the design of a unified synthetic strategy capable of producing several family members from a common synthetic intermediate.
520 $a Structurally, the xiamycin family members consist of a carbazole fused to a trans-decalin ring system. The difference between xiamycin A and oridamycin A is a single epimeric stereocenter at C16. It was envisioned that a key oxidative radical cyclization could produce both stereochemical patterns---with free-radical conditions generating the stereochemistry associated with oridamycin A, and chelated radical conditions producing the stereochemistry corresponding to xiamycin A.
520 $a The total synthesis of oridamycins A and B was completed, utilizing a free-radical cyclization that correctly set three contiguous stereocenters, including two quaternary carbons. The fused carbazole was produced using a 6?-electrocyclization/aromatization sequence. Finally, oridamycin B was accessed through a palladium-catalyzed, oxime-directed C-H oxidation.
590 $a School code: 0967.
650 4 $a Organic chemistry. $3 523952
650 4 $a Chemistry. $3 516420
690 $a 0490
690 $a 0485
710 2 $a Weill Medical College of Cornell University. $b Chemical Biology. $3 3351312
773 0 $t Dissertation Abstracts International $g 79-03B(E).
790 $a 0967
791 $a Ph.D.
792 $a 2018
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10635024