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Patent Ductus Arteriosus Ligation in...

Weisz, Dany.

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Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment./
作者:	Weisz, Dany.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	132 p.
附註:	Source: Masters Abstracts International, Volume: 56-03.
Contained By:	Masters Abstracts International56-03(E).
標題:	Medicine. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10194545
ISBN:	9781369666489

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
Weisz, Dany.

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 132 p.

Source: Masters Abstracts International, Volume: 56-03.

Thesis (M.Sc.)--University of Toronto (Canada), 2016.

This item is not available from ProQuest Dissertations & Theses.

Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.

ISBN: 9781369666489Subjects--Topical Terms:

641104
Medicine.

Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
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245 1 0 $a Patent Ductus Arteriosus Ligation in Extremely Preterm Infants and Death or Neurodevelopmental Impairment.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 132 p.
500 $a Source: Masters Abstracts International, Volume: 56-03.
500 $a Adviser: Prakesh S. Shah.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2016.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Objective: Evaluate the association between patent ductus arteriosus (PDA) ligation vs. medical management and neonatal and neurodevelopmental outcomes.
520 $a Methods: Retrospective cohort study of extremely preterm infants with PDA born between 2006-2012. The primary outcome was death or neurodevelopmental impairment (NDI) at 18-24 months. Secondary outcomes included death, chronic lung disease (CLD), and NDI. Multivariable logistic regression (MLR) analysis and marginal structural models (MSM) were used to adjust for perinatal and postnatal confounders.
520 $a Results: Of 754 infants with PDA, 184(24%) underwent ligation. Compared with medically treated infants, ligated infants had similar odds of death/NDI (aOR 0.83, 95%CI:0.52-1.32), NDI (aOR 1.27, 95%CI:0.78--2.06), and CLD (aOR 1.36, 95%CI:0.78--2.39), but lower mortality (aOR 0.09, 95%CI:0.04--0.21).
520 $a Conclusions: PDA ligation is not associated with adverse outcomes and may reduce mortality. Previously reported associations of ligation with increased morbidity are likely due to bias from confounding by indication, rather than a detrimental causal effect of ligation.
590 $a School code: 0779.
650 4 $a Medicine. $3 641104
650 4 $a Epidemiology. $3 568544
650 4 $a Biostatistics. $3 1002712
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793 $a English
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