東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Optogenetic stimulation, and control...

Selvaraj, Prashanth.

FindBook

Google Book

Amazon

博客來

Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex./
作者:	Selvaraj, Prashanth.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
面頁冊數:	83 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.
Contained By:	Dissertation Abstracts International77-08B(E).
標題:	Applied mathematics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10086043
ISBN:	9781339591766

Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex.
Selvaraj, Prashanth.

Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 83 p.

Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.

Thesis (Ph.D.)--University of California, Berkeley, 2015.

This item is not available from ProQuest Dissertations & Theses.

Epilepsy is a neural network disorder that manifests when certain elements (neuron types, sub-networks) malfunction or fail. Epileptiform activity, in turn, is characterized by the excessive synchronous firing of populations of neurons. In this dissertation, we present a mathematical model of the human cortex based on the activity of populations of neurons best captured at the meso-scale to study epileptic seizure dynamics. We then investigate further developments of the use of a spatially, temporally and cell type specific stimulation technique called optogenetics to trigger or to inhibit epileptiform activity in the cortical model.

ISBN: 9781339591766Subjects--Topical Terms:

2122814
Applied mathematics.

Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex.
LDR:03689nmm a2200349 4500 001 2159109
005 20180622095234.5
008 190424s2015 ||||||||||||||||| ||eng d
020 $a 9781339591766
035 $a (MiAaPQ)AAI10086043
035 $a (MiAaPQ)berkeley:15146
035 $a AAI10086043
040 $a MiAaPQ $c MiAaPQ
100 1 $a Selvaraj, Prashanth. $3 3346969
245 1 0 $a Optogenetic stimulation, and control or promotion of epileptiform activity, in a mean field model of the human cortex.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 83 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.
500 $a Adviser: Andrew J. Szeri.
502 $a Thesis (Ph.D.)--University of California, Berkeley, 2015.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Epilepsy is a neural network disorder that manifests when certain elements (neuron types, sub-networks) malfunction or fail. Epileptiform activity, in turn, is characterized by the excessive synchronous firing of populations of neurons. In this dissertation, we present a mathematical model of the human cortex based on the activity of populations of neurons best captured at the meso-scale to study epileptic seizure dynamics. We then investigate further developments of the use of a spatially, temporally and cell type specific stimulation technique called optogenetics to trigger or to inhibit epileptiform activity in the cortical model.
520 $a Optogenetics involves the genetic modification of a host neuron to express light activated ion channels. To incorporate this method of stimulation into the meso-scale cortical model, we first develop a scale free mathematical model of optogenetic channel dynamics, which enables study of micro-scale level optogenetic activity at the meso-scale. We then integrate the optogenetic model into the meso-scale cortical model to study the combined dynamics of cortico-optogenetic activity in time and two spatial dimensions. Through this combined model, we explore the efficacy of optogenetic stimulation in an open loop configuration to inhibit epileptic seizures. Next, we close the loop using techniques of classical control theory, and investigate the controllability of seizures in two parameter spaces that correspond well with patient seizure data. By basing our control effort on measurements of cortical activity that are clinically relevant, we aim to provide a physiologically safe and efficient way of seizure inhibition. We also study the dynamics of the combined cortico-optogenetic model using bifurcation analysis. We then explore the use of optogenetic stimulation as an excitatory technique to drive seizure like activity in a normally functioning cortical model. All of this makes a strong case for the consideration of optogenetics as a highly specific cortical stimulation modality in seizure research.
520 $a Finally, we present preliminary results from work that describes the link between cortical metabolic demands and cortical activity. A quantitative definition of this link will aid in reconciling the different temporal scales of electrode measurements and imaging techniques like functional magnetic resonance imaging, while also providing a clearer picture of the role of glucose and oxygen metabolism in multiple states of cortical activity, such as normal sleep, awake, and seizure states.
590 $a School code: 0028.
650 4 $a Applied mathematics. $3 2122814
650 4 $a Neurosciences. $3 588700
650 4 $a Biophysics. $3 518360
690 $a 0364
690 $a 0317
690 $a 0786
710 2 $a University of California, Berkeley. $b Mechanical Engineering. $3 1043692
773 0 $t Dissertation Abstracts International $g 77-08B(E).
790 $a 0028
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10086043