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Prenatal and Postnatal Exposure to C...

Tijerina, Pamella B.

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Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation./
Author:	Tijerina, Pamella B.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2017,
Description:	219 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
Contained By:	Dissertation Abstracts International78-12B(E).
Subject:	Toxicology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10258927
ISBN:	9780355127720

Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation.
Tijerina, Pamella B.

Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation. - Ann Arbor : ProQuest Dissertations & Theses, 2017 - 219 p.

Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.

Thesis (Ph.D.)--New York University, 2017.

Maternal exposure to elevated levels of PM2.5 during pregnancy has been associated with multiple adverse birth outcomes and infant mortality. Additionally, early life exposure to elevated levels of PM2.5 can impair lung function and neurodevelopment. Despite the mounting evidence surrounding PM-induced developmental immunotoxicology, previous studies have yet to evaluate the immune system vulnerability throughout the pre- and early post-natal periods. To more accurately reflect human exposure, timed-pregnant B6C 3F1 mice were exposed to concentrated fine-sized (PM 2.5) ambient particulate matter (CAPs) daily for 6 hr/d throughout gestation (GD 0-17) and after birth dams with their pups were exposed daily for 2 hr/d for a 10-period. At various time-points after exposure ceased, immune organs were recovered to determine the effects of PM2.5 exposure on immune profiles, including T-regulatory (TREG) and T-helper 17 (T H17) cells.

ISBN: 9780355127720Subjects--Topical Terms:

556884
Toxicology.

Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation.
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245 1 0 $a Prenatal and Postnatal Exposure to Concentrated Ambient Particulate Matter Alters Immune Profiles Associated with Global Inflammation.
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300 $a 219 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-12(E), Section: B.
500 $a Adviser: Judith T. Zelikoff.
502 $a Thesis (Ph.D.)--New York University, 2017.
520 $a Maternal exposure to elevated levels of PM2.5 during pregnancy has been associated with multiple adverse birth outcomes and infant mortality. Additionally, early life exposure to elevated levels of PM2.5 can impair lung function and neurodevelopment. Despite the mounting evidence surrounding PM-induced developmental immunotoxicology, previous studies have yet to evaluate the immune system vulnerability throughout the pre- and early post-natal periods. To more accurately reflect human exposure, timed-pregnant B6C 3F1 mice were exposed to concentrated fine-sized (PM 2.5) ambient particulate matter (CAPs) daily for 6 hr/d throughout gestation (GD 0-17) and after birth dams with their pups were exposed daily for 2 hr/d for a 10-period. At various time-points after exposure ceased, immune organs were recovered to determine the effects of PM2.5 exposure on immune profiles, including T-regulatory (TREG) and T-helper 17 (T H17) cells.
520 $a Results demonstrated that pre- and post-natal exposure to CAPs altered the developing immune system in a sex-specific manner. Namely, female CAPs offspring displayed a significant reduction in splenic index that was persistent until 15-wk-of-age, decreased B-cell maturation status at 6-wks-of-age, and a reduction in TREG cell associated markers in splenocytes through 10-wks-of-age. In contrast, male offspring exposed to CAPs demonstrated an increase in TH17-associated cellular markers and cytokines at 10-wk-of-age.
520 $a Subsequent behavioral testing in adult male and female offspring demonstrated that social behaviors were significantly altered by CAPs exposure. Effects on social behavior were supported by altered inflammatory gene expression observed in the hippocampus of male and female offspring. Notably, relative expression of Il6 and Tnfa was increased in the hippocampus region of female offspring after CAPs exposure.
520 $a The observed sex-specific alterations help to illustrate the gaps in previous developmental studies that focus on PM2.5-induced immune effects in male offspring. Findings from this study suggest that early life exposure to particulate air pollution adversely and persistently impacts the developing immune system. Moreover, the observed differences between the sexes indicate important gaps in current data examining PM-induced developmental immune toxicity.
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