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Drosophila midline development: The ...

Moawad, Amanda Christine.

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Drosophila midline development: The role of 18-Wheeler and an optimized protocol for transcriptome analysis.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Drosophila midline development: The role of 18-Wheeler and an optimized protocol for transcriptome analysis./
作者:	Moawad, Amanda Christine.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
面頁冊數:	73 p.
附註:	Source: Masters Abstracts International, Volume: 55-05.
Contained By:	Masters Abstracts International55-05(E).
標題:	Developmental biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10119781
ISBN:	9781339809724

Drosophila midline development: The role of 18-Wheeler and an optimized protocol for transcriptome analysis.
Moawad, Amanda Christine.

Drosophila midline development: The role of 18-Wheeler and an optimized protocol for transcriptome analysis. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 73 p.

Source: Masters Abstracts International, Volume: 55-05.

Thesis (M.S.)--The University of North Carolina at Chapel Hill, 2016.

The developing midline of Drosophila consists of diverse cell types that must migrate and differentiate appropriately to form a functional central nervous system. Despite the paucity of midline cells, much is unknown about how these cells migrate to their final locations and acquire fates. In a previous RNA-sequencing screen, we found that 18-Wheeler (18w), a Toll-family receptor, is present in the midline during embryonic development. Fluorescence in situ hybridizations and genetic analyses revealed that 18w is expressed posteriorly in segments in the median neuroblast. 18w overexpression led to midline disorganization, while heterozygous 18w loss of function mutants showed no phenotype, indicating that one wild-type copy of 18w is sufficient to maintain function.

ISBN: 9781339809724Subjects--Topical Terms:

592588
Developmental biology.

Drosophila midline development: The role of 18-Wheeler and an optimized protocol for transcriptome analysis.
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