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Total synthesis of natural products ...

Giltrap, Andrew.

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Total synthesis of natural products with antimicrobial activity

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Total synthesis of natural products with antimicrobial activity/ by Andrew Giltrap.
作者:	Giltrap, Andrew.
出版者:	Singapore :Springer Singapore : : 2018.,
面頁冊數:	xxiv, 268 p. :ill. (some col.), digital ;24 cm.
內容註:	Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.
Contained By:	Springer eBooks
標題:	Natural products. -
電子資源:	http://dx.doi.org/10.1007/978-981-10-8806-3
ISBN:	9789811088063

Total synthesis of natural products with antimicrobial activity
Giltrap, Andrew.

Total synthesis of natural products with antimicrobial activity[electronic resource] /by Andrew Giltrap. - Singapore :Springer Singapore :2018. - xxiv, 268 p. :ill. (some col.), digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Total Synthesis of Teixobactin -- Synthesis of Deshydroxy Skyllamycins A-C -- Total Synthesis of Skyllamycins A-C -- Experimental.

This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

ISBN: 9789811088063

Standard No.: 10.1007/978-981-10-8806-3doiSubjects--Topical Terms:

604625
Natural products.

LC Class. No.: QD375 / .G558 2018

Dewey Class. No.: 615.792

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