東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Human epigenomics

Carlberg, Carsten.

FindBook

Google Book

Amazon

博客來

Human epigenomics

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Human epigenomics/ by Carsten Carlberg, Ferdinand Molnar.
作者:	Carlberg, Carsten.
其他作者:	Molnar, Ferdinand.
出版者:	Singapore :Springer Singapore : : 2018.,
面頁冊數:	xix, 223 p. :ill., digital ;24 cm.
內容註:	What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics.
Contained By:	Springer eBooks
標題:	Epigenetics. -
電子資源:	http://dx.doi.org/10.1007/978-981-10-7614-5
ISBN:	9789811076145

Human epigenomics
Carlberg, Carsten.

Human epigenomics[electronic resource] /by Carsten Carlberg, Ferdinand Molnar. - Singapore :Springer Singapore :2018. - xix, 223 p. :ill., digital ;24 cm.

What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics.

The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin) Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule "a picture tells more than thousand words". The content of the book is based on the lecture course "Molecular Medicine and Genetics" that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks "Mechanisms of Gene Regulation" (ISBN 978-94-017-7741-4) and "Nutrigenomics" (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine.

ISBN: 9789811076145

Standard No.: 10.1007/978-981-10-7614-5doiSubjects--Topical Terms:

1568224
Epigenetics.

LC Class. No.: QH447

Dewey Class. No.: 572.86

Human epigenomics
LDR:03668nmm a2200313 a 4500 001 2133727
003 DE-He213
005 20180821151717.0
006 m d
007 cr nn 008maaau
008 181005s2018 si s 0 eng d
020 $a 9789811076145 $q (electronic bk.)
020 $a 9789811076138 $q (paper)
024 7 $a 10.1007/978-981-10-7614-5 $2 doi
035 $a 978-981-10-7614-5
040 $a GP $c GP
041 0 $a eng
050 4 $a QH447
072 7 $a MFN $2 bicssc
072 7 $a MED107000 $2 bisacsh
082 0 4 $a 572.86 $2 23
090 $a QH447 $b .C278 2018
100 1 $a Carlberg, Carsten. $3 2057498
245 1 0 $a Human epigenomics $h [electronic resource] / $c by Carsten Carlberg, Ferdinand Molnar.
260 $a Singapore : $b Springer Singapore : $b Imprint: Springer, $c 2018.
300 $a xix, 223 p. : $b ill., digital ; $c 24 cm.
505 0 $a What is epigenomics? -- Methods and applications of epigenomics -- The structure of chromatin -- DNA methylation -- The histone code -- Chromatin modifiers -- Chromatin remodelers and organizers -- Embryogenesis and cellular differentiation -- Population epigenomics and aging -- Cancer epigenomics -- Neuroepigenetics -- Epigenomics of immune function -- Nutritional epigenomics.
520 $a The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin) Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule "a picture tells more than thousand words". The content of the book is based on the lecture course "Molecular Medicine and Genetics" that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks "Mechanisms of Gene Regulation" (ISBN 978-94-017-7741-4) and "Nutrigenomics" (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a usefull reference for individuals working in biomedicine.
650 0 $a Epigenetics. $3 1568224
650 0 $a Human genetics. $3 518846
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Human Genetics. $3 891169
650 2 4 $a Molecular Medicine. $3 890952
700 1 $a Molnar, Ferdinand. $3 2057499
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-981-10-7614-5
950 $a Biomedical and Life Sciences (Springer-11642)