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Development of PET neuroimaging meth...

Ouyang, Yu.

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Development of PET neuroimaging methods for stroke and neuroinflammation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of PET neuroimaging methods for stroke and neuroinflammation./
作者:	Ouyang, Yu.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
面頁冊數:	125 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
Contained By:	Dissertation Abstracts International77-02B(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3723695
ISBN:	9781339065779

Development of PET neuroimaging methods for stroke and neuroinflammation.
Ouyang, Yu.

Development of PET neuroimaging methods for stroke and neuroinflammation. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 125 p.

Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2015.

This item is not available from ProQuest Dissertations & Theses.

Neuroimaging techniques and applications continue to be explored and further refined as the underlying technology advances. Positron emission tomography (PET) is a highly sensitive imaging modality that has been used both clinically and preclinically to elucidate underlying biochemistry and physiology. Developments in multimodality PET and magnetic resonance imaging (MRI) are pushing the limits of sensitivity and spatial resolution, and have allowed simultaneous acquisition of multimodal data. Within the brain, renewed focus on glial cells and their involvement in a variety of pathologies has resulted in newly proposed applications for existing radiotracers, continued improvement of existing radioligands for neuroreceptor targets, and the development of accompanying pharmacokinetic modeling techniques.

ISBN: 9781339065779Subjects--Topical Terms:

535387
Biomedical engineering.

Development of PET neuroimaging methods for stroke and neuroinflammation.
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245 1 0 $a Development of PET neuroimaging methods for stroke and neuroinflammation.
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500 $a Source: Dissertation Abstracts International, Volume: 77-02(E), Section: B.
500 $a Adviser: Simon R. Cherry.
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506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Neuroimaging techniques and applications continue to be explored and further refined as the underlying technology advances. Positron emission tomography (PET) is a highly sensitive imaging modality that has been used both clinically and preclinically to elucidate underlying biochemistry and physiology. Developments in multimodality PET and magnetic resonance imaging (MRI) are pushing the limits of sensitivity and spatial resolution, and have allowed simultaneous acquisition of multimodal data. Within the brain, renewed focus on glial cells and their involvement in a variety of pathologies has resulted in newly proposed applications for existing radiotracers, continued improvement of existing radioligands for neuroreceptor targets, and the development of accompanying pharmacokinetic modeling techniques.
520 $a In this work, several related neuroimaging techniques and tracers were evaluated and developed. Recent work in rodent brain injury models demonstrated elevated lesion uptake of 2-[18F]fluoroacetate ([18 F]FACE), suggesting its possible use for specifically imaging glial metabolism. To assess this hypothesis, we evaluated [18F]FACE kinetics in rodent models of cerebral hypoxia-ischemia. In addition, due to the rapid and variable nature of injury in this animal model, acquisition of both PET and MRI data must be performed simultaneously in order to meaningfully correlate the resulting images. Inter-animal variability in the hypoxic ischemic injury due to vascular differences restricts the ability to analyze multi-modal data and observe changes to a group-wise approach if data is not acquired simultaneously in individual subjects. We present a method for simultaneous imaging of diffusion-weighted MRI and [18F]FDG uptake data in the same animal before, during, and after the hypoxic challenge in order to interrogate immediate physiological changes.
520 $a Imaging of the 18-kDa translocator protein (TSPO) is standard for preclinical assessment of neuroinflammation. Quantification of radioligand binding by estimating the binding potential of the non-displaceable compartment ( BPND) is potentially valuable for measuring the neuroinflammatory response following organophosphate (OP) exposure. [18F]PBR111 is a recently developed second generation TSPO radioligand and it has been previously evaluated in other animal models of neuroinflammation. We present a comparison of input function and reference tissue based methods for estimation of [18F]PBR111 BPND and related parameters in this animal model.
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