東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Regulation of hippocampal pyramidal ...

Yamada-Hanff, Jason.

FindBook

Google Book

Amazon

博客來

Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances./
作者:	Yamada-Hanff, Jason.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2015,
面頁冊數:	137 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3700550
ISBN:	9781321705447

Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances.
Yamada-Hanff, Jason.

Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances. - Ann Arbor : ProQuest Dissertations & Theses, 2015 - 137 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--Harvard University, 2015.

The single neuron's decision of whether to fire an action potential is the central computation underlying neural function. This transformation of synaptic inputs into an output pattern of spikes is controlled by the interaction of synaptic input with the neuron's intrinsic membrane properties. During this process, the neural membrane is not just a passive receiver of input but reacts dynamically to input via the activity and modulation of ion channels that are active below the action potential threshold. The goal of this work was to examine how such subthreshold voltage-dependent conductances contribute to the electrical function of hippocampal CA1 pyramidal neurons.

ISBN: 9781321705447Subjects--Topical Terms:

588700
Neurosciences.

Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances.
LDR:03267nmm a2200313 4500 001 2124102
005 20171023101709.5
008 180830s2015 ||||||||||||||||| ||eng d
020 $a 9781321705447
035 $a (MiAaPQ)AAI3700550
035 $a AAI3700550
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yamada-Hanff, Jason. $3 3286080
245 1 0 $a Regulation of hippocampal pyramidal neuron excitability by subthreshold voltage-dependent conductances.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2015
300 $a 137 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500 $a Adviser: Wade Regehr.
502 $a Thesis (Ph.D.)--Harvard University, 2015.
520 $a The single neuron's decision of whether to fire an action potential is the central computation underlying neural function. This transformation of synaptic inputs into an output pattern of spikes is controlled by the interaction of synaptic input with the neuron's intrinsic membrane properties. During this process, the neural membrane is not just a passive receiver of input but reacts dynamically to input via the activity and modulation of ion channels that are active below the action potential threshold. The goal of this work was to examine how such subthreshold voltage-dependent conductances contribute to the electrical function of hippocampal CA1 pyramidal neurons.
520 $a Spontaneous firing is a hallmark function of subthreshold inward conductances as they can drive depolarization in the absence of synaptic input. Although CA1 pyramidal neurons usually require input to fire, cholinergic modulation increases their excitability and can elicit spontaneous activity. Chapter 2 explores the ionic mechanisms of this spontaneous firing induced by muscarinic stimulation. Muscarinic modulation activates a current that shifts the entire steady-state current-voltage relationship for the cell so that inward current flows at all subthreshold voltages. This inward shift unveils the activity of a large persistent sodium current which drives depolarization. Using recordings of the cell's own firing as a voltage command, I show directly that persistent sodium current, and not hyperpolarization-activated cation current, underlies the slow subthreshold depolarization that drives spontaneous activity in these cells.
520 $a The activity of subthreshold voltage-dependent conductances makes the subthreshold membrane an active participant in input integration. In Chapter 3, I explore the contribution of voltage-dependent conductances in the context of natural (and naturalistic) membrane behavior. I show that the subthreshold activity of voltage-dependent conductances confers a voltage dependence on intrinsic membrane properties. Further, to account for time-dependent properties, I directly measure the contribution of persistent sodium current and hyperpolarization-activated current to membrane behavior during a naturalistic stimulus delivered via dynamic clamp, as well as during in vivo membrane behavior.
590 $a School code: 0084.
650 4 $a Neurosciences. $3 588700
650 4 $a Biophysics. $3 518360
690 $a 0317
690 $a 0786
710 2 $a Harvard University. $b Medical Sciences. $3 3181716
773 0 $t Dissertation Abstracts International $g 76-09B(E).
790 $a 0084
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3700550