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A biochemical linkage between methan...

Oza, Javin Pradip.

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A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea./
作者:	Oza, Javin Pradip.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2012,
面頁冊數:	214 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-02(E), Section: B.
Contained By:	Dissertation Abstracts International74-02B(E).
標題:	Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3540206
ISBN:	9781267648686

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.
Oza, Javin Pradip.

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea. - Ann Arbor : ProQuest Dissertations & Theses, 2012 - 214 p.

Source: Dissertation Abstracts International, Volume: 74-02(E), Section: B.

Thesis (Ph.D.)--University of California, Santa Barbara, 2012.

Hydrogenotrophic methanogens possessing the hydrogen-dependent dehydrogenase Hmd also encode paralogs of this protein whose function is poorly understood. Here we present biochemical evidence that the two inactive Hmd paralogs of Methanocaldococcus jannaschii, HmdII and HmdIII, form binary and ternary complexes with several components of the protein translation apparatus. HmdII and HmdIII, but not the active dehydrogenase Hmd, bind with micromolar binding affinities to a number of tRNAs and form ternary complexes with tRNA(Pro) and prolyl-tRNA synthetase (ProRS). Fluorescence spectroscopy experiments also suggest that binding of HmdII and ProRS involves distinct binding determinants on the tRNA. These biochemical data suggest the possibility of a regulatory link between energy production and protein translation pathways that may allow a rapid cellular response to altered environmental conditions.

ISBN: 9781267648686Subjects--Topical Terms:

518028
Biochemistry.

A biochemical linkage between methanogenesis and protein synthesis in hydrogenotrophic archaea.
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