東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Role of MicroRNA-17-92 cluster in th...

Varshney, Jyotika.

Linked to FindBook

Google Book

Amazon

博客來

Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression./
Author:	Varshney, Jyotika.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	164 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
Contained By:	Dissertation Abstracts International78-03B(E).
Subject:	Genetics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10153314
ISBN:	9781369084504

Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression.
Varshney, Jyotika.

Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 164 p.

Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.

Thesis (Ph.D.)--University of Minnesota, 2016.

The acquisition of cancer traits in rare cells is accompanied and caused by a huge variety of driver genetic events. These include chromosomal deletions, translocations, point mutations, and insertions. The acquisition of a metastatic phenotype is currently the biggest problem in cancer treatment. However, genetic driver events that cause metastasis have been elusive and thus treatment to stop metastasis is not available in many cases. It has become recently appreciated that certain cancer traits are conferred by changes in microRNAs (miRNAs). MicroRNAs are a class of small endogenous RNAs that regulate the expression of other genes by binding to and destabilizing mRNAs and/or suppressing their translation. In this work we used a comparative oncogenomics approach to discover miRNAs that cause osteosarcoma progression and investigated their function in vivo and in vitro. In the first chapter, I review the evidence for a genetic origin of human cancer. Then, I review hallmarks of cancer, with a focus on metastasis and the failure of DNA sequence changes to fully explain metastasic process. Then, I review the role of miRNAs in biology and cancer development. The second chapter focuses on osteosarcoma development, the known roles that miRNAs play in this disease, and the chance that this understanding could lead to better treatments. The third chapter describes my investigation into the role of the miR-17-92 cluster in OS progression and metastasis. Finally, in the fourth chapter, I provide a summary and future perspectives for this work.

ISBN: 9781369084504Subjects--Topical Terms:

530508
Genetics.

Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression.
LDR:02500nmm a2200301 4500 001 2116773
005 20170508081326.5
008 180830s2016 ||||||||||||||||| ||eng d
020 $a 9781369084504
035 $a (MiAaPQ)AAI10153314
035 $a AAI10153314
040 $a MiAaPQ $c MiAaPQ
100 1 $a Varshney, Jyotika. $3 3278515
245 1 0 $a Role of MicroRNA-17-92 cluster in the Osteosarcoma Development and Progression.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-03(E), Section: B.
500 $a Adviser: David A. Largaespada.
502 $a Thesis (Ph.D.)--University of Minnesota, 2016.
520 $a The acquisition of cancer traits in rare cells is accompanied and caused by a huge variety of driver genetic events. These include chromosomal deletions, translocations, point mutations, and insertions. The acquisition of a metastatic phenotype is currently the biggest problem in cancer treatment. However, genetic driver events that cause metastasis have been elusive and thus treatment to stop metastasis is not available in many cases. It has become recently appreciated that certain cancer traits are conferred by changes in microRNAs (miRNAs). MicroRNAs are a class of small endogenous RNAs that regulate the expression of other genes by binding to and destabilizing mRNAs and/or suppressing their translation. In this work we used a comparative oncogenomics approach to discover miRNAs that cause osteosarcoma progression and investigated their function in vivo and in vitro. In the first chapter, I review the evidence for a genetic origin of human cancer. Then, I review hallmarks of cancer, with a focus on metastasis and the failure of DNA sequence changes to fully explain metastasic process. Then, I review the role of miRNAs in biology and cancer development. The second chapter focuses on osteosarcoma development, the known roles that miRNAs play in this disease, and the chance that this understanding could lead to better treatments. The third chapter describes my investigation into the role of the miR-17-92 cluster in OS progression and metastasis. Finally, in the fourth chapter, I provide a summary and future perspectives for this work.
590 $a School code: 0130.
650 4 $a Genetics. $3 530508
650 4 $a Veterinary science. $3 3172798
650 4 $a Molecular biology. $3 517296
690 $a 0369
690 $a 0778
690 $a 0307
710 2 $a University of Minnesota. $b Veterinary Medicine. $3 1682756
773 0 $t Dissertation Abstracts International $g 78-03B(E).
790 $a 0130
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10153314