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Developmental Mechanobiology of the ...

Hubbell, Zachariah Randall.

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Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus./
Author:	Hubbell, Zachariah Randall.
Published:	Ann Arbor : ProQuest Dissertations & Theses, : 2016,
Description:	334 p.
Notes:	Source: Dissertation Abstracts International, Volume: 78-02(E), Section: A.
Contained By:	Dissertation Abstracts International78-02A(E).
Subject:	Forensic anthropology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10145031
ISBN:	9781369005912

Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus.
Hubbell, Zachariah Randall.

Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus. - Ann Arbor : ProQuest Dissertations & Theses, 2016 - 334 p.

Source: Dissertation Abstracts International, Volume: 78-02(E), Section: A.

Thesis (Ph.D.)--The Ohio State University, 2016.

The significance of the microstructural interface between trabecular and cortical bone in the long bone metaphyses as a mechanically-adapted feature of skeletal morphology is largely unexplored, despite the role of these structures as critical for the transmission of axial loads from the trabecular network to the cortical diaphysis. These cortical-trabecular junctions (CTJs) are studied here within the context of bone ontogeny and from the perspective of mechanobiology, which seeks to interpret skeletal morphology as a product of its mechanical-functional demands.

ISBN: 9781369005912Subjects--Topical Terms:

791531
Forensic anthropology.

Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus.
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100 1 $a Hubbell, Zachariah Randall. $3 3278497
245 1 0 $a Developmental Mechanobiology of the Metaphyseal Cortical-Trabecular Interface in the Human Proximal Tibia and Proximal Humerus.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2016
300 $a 334 p.
500 $a Source: Dissertation Abstracts International, Volume: 78-02(E), Section: A.
500 $a Adviser: Clark Larsen.
502 $a Thesis (Ph.D.)--The Ohio State University, 2016.
520 $a The significance of the microstructural interface between trabecular and cortical bone in the long bone metaphyses as a mechanically-adapted feature of skeletal morphology is largely unexplored, despite the role of these structures as critical for the transmission of axial loads from the trabecular network to the cortical diaphysis. These cortical-trabecular junctions (CTJs) are studied here within the context of bone ontogeny and from the perspective of mechanobiology, which seeks to interpret skeletal morphology as a product of its mechanical-functional demands.
520 $a Aligned to the theoretical paradigm of bone functional adaptation, which states that bone adapts to its mechanical environment during life, this study tests several hypotheses regarding various associations between body mass and age on the one hand and various measures of CTJ structure on the other, including elements of cortical-trabecular connectivity and bone volume distribution. Anatomical site variability and mechanical adaptability in CTJ ontogeny was further addressed by examining these skeletal features in two separate skeletal elements with vastly different mechanical functions.
520 $a This study was performed conducted using the Norris Farms (NF) No. 36 skeletal series, an archaeological sample of skeletons derived from a late-prehistoric group of Oneota Native Americans living in present day west-central Illinois ca. 1300 A.D. Micro-computed tomography was used to acquire high-resolution images of NF adult and sub-adult tibiae and humeri for non-invasive and non-destructive analysis of internal bone microstructure. Two computer image analysis programs (Avizo Fire 8.1.1 and ImageJ 1.49v) were used to isolate and quantify volumes of interest, and all statistical analyses were carried out in SPSS v.22.
520 $a Results show a complicated picture of CTJ ontogeny in which mechanical adaptability appears to be an important driver of CTJ structural development, but not to the exclusion of other, less clear factors. CTJs display a certain degree of mechanical sensitivity during the growth period that appears to disappear shortly following attainment of skeletal maturity. Pervasive differences regarding various characteristics of CTJ structure in the tibia versus humerus lend further support to the importance of anatomical site-specificity and local mechanical environment for shaping the cortical-trabecular interface. CTJ development is likely both guided and constrained by growth phenomena such as metaphyseal trabecular coalescence, which is itself an element of the broader mechanism of mechanically-sensitive endochondral ossification. Cessation of these processes following skeletal maturation is attributed to the view of relatively unchanging CTJ microarchitecture during adulthood.
590 $a School code: 0168.
650 4 $a Forensic anthropology. $3 791531
650 4 $a Soil sciences. $3 2122699
650 4 $a Physiology. $3 518431
650 4 $a Biomechanics. $3 548685
650 4 $a Archaeology. $3 558412
650 4 $a Physical anthropology. $3 518358
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710 2 $a The Ohio State University. $b Anthropology. $3 2101181
773 0 $t Dissertation Abstracts International $g 78-02A(E).
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791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10145031