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Designing DNA Bonds for the Assembly...

Thaner, Ryan Vachon.

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Designing DNA Bonds for the Assembly of Nanoparticle and Organic Conjugates.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Designing DNA Bonds for the Assembly of Nanoparticle and Organic Conjugates./
作者:	Thaner, Ryan Vachon.
面頁冊數:	209 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:	Dissertation Abstracts International77-10B(E).
標題:	Nanoscience. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10117329
ISBN:	9781339787312

Designing DNA Bonds for the Assembly of Nanoparticle and Organic Conjugates.
Thaner, Ryan Vachon.

Designing DNA Bonds for the Assembly of Nanoparticle and Organic Conjugates. - 209 p.

Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.

Thesis (Ph.D.)--Northwestern University, 2016.

This item is not available from ProQuest Dissertations & Theses.

This thesis describes investigations centered on the rational design, synthesis, and fundamental study of the self-assembly behavior of two classes of oligonucleotide conjugates made from spherical gold nanoparticles and rigid organic molecules. Through various strategies in bioconjugate chemistry, modified oligonucleotides are attached to these scaffolds such that the well-known base-pairing interactions of DNA nucleobases are used as programmable bonding elements to direct the formation of higher-order materials. Unlike the majority of the research to date, the work described herein emphasizes the role of the oligonucleotide "bonds" during assembly as opposed to the effects of the underlying scaffold. Through methodical iterations in the design of these programmable ligands and correlations with assembly behavior, design principles, methodologies, and insight are established that provide new paradigms and avenues for controlling the arrangement of molecular and nanoscale systems using oligonucleotides.

ISBN: 9781339787312Subjects--Topical Terms:

587832
Nanoscience.

Designing DNA Bonds for the Assembly of Nanoparticle and Organic Conjugates.
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500 $a Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500 $a Advisers: Chad A. Mirkin; SonBinh T. Nguyen.
502 $a Thesis (Ph.D.)--Northwestern University, 2016.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a This thesis describes investigations centered on the rational design, synthesis, and fundamental study of the self-assembly behavior of two classes of oligonucleotide conjugates made from spherical gold nanoparticles and rigid organic molecules. Through various strategies in bioconjugate chemistry, modified oligonucleotides are attached to these scaffolds such that the well-known base-pairing interactions of DNA nucleobases are used as programmable bonding elements to direct the formation of higher-order materials. Unlike the majority of the research to date, the work described herein emphasizes the role of the oligonucleotide "bonds" during assembly as opposed to the effects of the underlying scaffold. Through methodical iterations in the design of these programmable ligands and correlations with assembly behavior, design principles, methodologies, and insight are established that provide new paradigms and avenues for controlling the arrangement of molecular and nanoscale systems using oligonucleotides.
520 $a The first chapter of this thesis introduces the concept of using DNA as a programmable ligand for materials synthesis and the two classes of conjugates that were employed in this research. Chapter two describes how systematic alterations to the oligonucleotide design affect the assembly process of nanoparticle-based systems. Chapter three builds upon the DNA-nanoparticle system and presents a new design principle: when the DNA employed is sufficiently long and flexible, entropic contributions to the free energy of crystallization are significant and lead to lattice formation that is unexpected based upon enthalpic arguments. The fourth chapter focuses on DNA-organic conjugates and the synthetic methodology that was developed to make these building blocks with unprecedented ease as well as in a high-yielding, scalable, and general fashion. The synthesis is coupled with demonstrations of the tunable assembly of these conjugates into polymeric nanoparticles that offer promise in biological applications. Chapter five contains an example of how both types of conjugates can be utilized in the synthesis of hybrid materials where branched organic molecules are incorporated into the DNA-nanoparticle platform. The final chapter describes the implications of this work and suggests new directions for both types of conjugates. Descriptions of the materials and methods used to synthesize these materials as well as further data to support the conclusions made in each chapter are included as appendices.
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