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A Magnetophoretic Bioseparation Chip.

Guo, Chuan.

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A Magnetophoretic Bioseparation Chip.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A Magnetophoretic Bioseparation Chip./
Author:	Guo, Chuan.
Description:	84 p.
Notes:	Source: Masters Abstracts International, Volume: 53-03.
Contained By:	Masters Abstracts International53-03(E).
Subject:	Mechanical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1560826
ISBN:	9781321046229

A Magnetophoretic Bioseparation Chip.
Guo, Chuan.

A Magnetophoretic Bioseparation Chip. - 84 p.

Source: Masters Abstracts International, Volume: 53-03.

Thesis (M.S.)--Southern Illinois University at Edwardsville, 2014.

This thesis presents the modeling, design, fabrication, and testing of a magnetophoretic bioseparation chip for isolation of biomaterials such as cells, antigens or DNA from their native environment. This microfluidic-based bioseparation device has several unique features, including locally engineered magnetic field gradients and a continuous flow with a buffer switching scheme to improve the performance of the separation process. The overall dimensions of the device are 25 mm by 75 mm by 1 mm. The cell purity was found to increase with increasing the sample flow rate. However, the cell recovery decreases with an increase in the flow rate. A compressive parametric study is performed to investigate the effects of channel height, substrate thickness, magnetic bead size, cell size, flow rate, and the number of beads per cell on the cell separation performance.

ISBN: 9781321046229Subjects--Topical Terms:

649730
Mechanical engineering.

A Magnetophoretic Bioseparation Chip.
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020 $a 9781321046229
035 $a (MiAaPQ)AAI1560826
035 $a AAI1560826
040 $a MiAaPQ $c MiAaPQ
100 1 $a Guo, Chuan. $3 3194229
245 1 2 $a A Magnetophoretic Bioseparation Chip.
300 $a 84 p.
500 $a Source: Masters Abstracts International, Volume: 53-03.
500 $a Adviser: Jeff Darabi.
502 $a Thesis (M.S.)--Southern Illinois University at Edwardsville, 2014.
520 $a This thesis presents the modeling, design, fabrication, and testing of a magnetophoretic bioseparation chip for isolation of biomaterials such as cells, antigens or DNA from their native environment. This microfluidic-based bioseparation device has several unique features, including locally engineered magnetic field gradients and a continuous flow with a buffer switching scheme to improve the performance of the separation process. The overall dimensions of the device are 25 mm by 75 mm by 1 mm. The cell purity was found to increase with increasing the sample flow rate. However, the cell recovery decreases with an increase in the flow rate. A compressive parametric study is performed to investigate the effects of channel height, substrate thickness, magnetic bead size, cell size, flow rate, and the number of beads per cell on the cell separation performance.
590 $a School code: 0509.
650 4 $a Mechanical engineering. $3 649730
650 4 $a Biomechanics. $3 548685
650 4 $a Engineering. $3 586835
690 $a 0548
690 $a 0648
690 $a 0537
710 2 $a Southern Illinois University at Edwardsville. $b Mechanical and Industrial Engineering. $3 2097590
773 0 $t Masters Abstracts International $g 53-03(E).
790 $a 0509
791 $a M.S.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1560826