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Sugar intake, inflammation, and depr...

Joseph, Janine Marie.

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Sugar intake, inflammation, and depression in breast cancer patients.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Sugar intake, inflammation, and depression in breast cancer patients./
作者:	Joseph, Janine Marie.
面頁冊數:	93 p.
附註:	Source: Masters Abstracts International, Volume: 54-06.
Contained By:	Masters Abstracts International54-06(E).
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1594733
ISBN:	9781321921762

Sugar intake, inflammation, and depression in breast cancer patients.
Joseph, Janine Marie.

Sugar intake, inflammation, and depression in breast cancer patients. - 93 p.

Source: Masters Abstracts International, Volume: 54-06.

Thesis (M.S.)--State University of New York at Buffalo, 2015.

BACKGROUND: High sugar intake and depressive disorders are both prevalent public health concerns. Sugar consumption and diets high in starch, pasta, fast food, baked goods, and carbohydrates have been associated with depression and other adverse mental states. Dietary sugar intake and sweets have also been positively associated with inflammation. Markers of inflammation have also been associated with depression. Few studies have examined the relationship between sugar intake and depression independent of other aspects of diet, and no study has considered inflammation as a possible mediator of this association.

ISBN: 9781321921762Subjects--Topical Terms:

568544
Epidemiology.

Sugar intake, inflammation, and depression in breast cancer patients.
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100 1 $a Joseph, Janine Marie. $3 3193694
245 1 0 $a Sugar intake, inflammation, and depression in breast cancer patients.
300 $a 93 p.
500 $a Source: Masters Abstracts International, Volume: 54-06.
500 $a Adviser: Susan McCann.
502 $a Thesis (M.S.)--State University of New York at Buffalo, 2015.
520 $a BACKGROUND: High sugar intake and depressive disorders are both prevalent public health concerns. Sugar consumption and diets high in starch, pasta, fast food, baked goods, and carbohydrates have been associated with depression and other adverse mental states. Dietary sugar intake and sweets have also been positively associated with inflammation. Markers of inflammation have also been associated with depression. Few studies have examined the relationship between sugar intake and depression independent of other aspects of diet, and no study has considered inflammation as a possible mediator of this association.
520 $a OBJECTIVE/HYPOTHESES: The objective of this research was to investigate the association between sugar intake, independent of other aspects of diet, and prevalence of self-reported depression, and to examine inflammation as a possible mediator of the association. The following hypotheses were tested: 1) Compared to women with lower dietary intake of total sugars, women with higher dietary intake of total sugars have greater odds of self-reported depression. 2) Compared to women with lower plasma levels of markers of inflammation, women with higher plasma levels of markers of inflammation have higher dietary intake of total sugars. 3) Compared to women with lower plasma levels of markers of inflammation, women with higher plasma levels of markers of inflammation have greater odds of self-reported depression. 4) The association between dietary intake of total sugars and self-reported depression is attenuated when controlling for markers of inflammation, suggesting that the association between sugar intake and depression is mediated by inflammation.
520 $a METHODS: This cross-sectional analysis was conducted in a sample of recently diagnosed female breast cancer patients ages 18 and older, drawn from The Women's Health after Breast Cancer Study (n = 392). Diet, self-reported depression, and inflammation were assessed using a semi-quantitative food frequency questionnaire, a validated depression questionnaire, and a panel of 25 pro- and anti-inflammatory cytokines, respectively. Descriptive statistics were used to examine differences in demographic and other characteristics between participants at different levels of sugar intake and depression. The association between sugar intake and depression was estimated using logistic regression, with adjustment for potential dietary and other confounders. The association between markers of inflammation and sugar intake was estimated using age-adjusted analysis of covariance. The association between markers of inflammation and depression was estimated using age-adjusted logistic regression. The role of inflammatory markers as potential mediators of the sugar-depression association was examined by means of logistic regression, with adjustment for the same covariates as in the sugar-depression models but with the addition of cytokines and ratios found to be significantly related to both sugar intake and depression.
520 $a RESULTS: After adjusting for potential demographic, dietary, anthropometric, and lifestyle confounders, total sugar intake was not associated with depression. Comparing quartile 4 to quartile 1 of sugar intake, the odds ratio (OR) (95% confidence interval (CI)) was 0.87 (0.43,1.76) for odds of any level of depression and 0.51 (0.20,1.32) for odds of clinically relevant or major depression. In the age-adjusted analysis of the association between sugar intake and markers of inflammation, only the ratio of the cytokines interleukin 6 and interleukin 10 (IL6/IL10) was inversely associated with sugar intake with intake ranging from 23.07% of daily kilocalories for subjects in the lowest tertile of this cytokine ratio to 20.82% for those in the highest tertile (overall p-value=0.0295). In the age-adjusted analysis of the association between cytokines and depression, only IL6/IL10 was significantly related to depression. Comparing highest versus lowest tertile of IL6/IL10, the age-adjusted OR (90% CI) for the association between IL6/IL10 and any depression was 1.83 (1.15,2.92); for clinically relevant or major depression, the association was 2.99 (1.53,5.82). Controlling for IL6/IL10 in the adjusted logistic models of the association between sugar and depression did little to alter the overall association between sugar and depression, suggesting that this marker of inflammation did not mediate the association. Comparing quartile 4 to quartile 1 of sugar intake, the cytokine-adjusted OR (95% CI) was 0.93 (0.46,1.88) for any level of depression and 0.53 (0.20,1.40) for clinically relevant or major depression. We found evidence that different types of naturally occurring and added sugar might have different associations with depression, based on analysis of food groups.
520 $a SIGNIFICANCE: This analysis adds to the body of knowledge on diet, inflammation and depression, and how different types of naturally occurring and added sugars might have different associations with depression. Given the heavy burden that depression places on both individuals and society as a whole, and the high prevalence of the exposure under consideration, research on the association between sugar and depression has significant potential to benefit the public's health. (Abstract shortened by UMI.).
590 $a School code: 0656.
650 4 $a Epidemiology. $3 568544
650 4 $a Mental health. $3 534751
650 4 $a Nutrition. $3 517777
650 4 $a Oncology. $3 751006
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710 2 $a State University of New York at Buffalo. $b Epidemiology. $3 3192895
773 0 $t Masters Abstracts International $g 54-06(E).
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793 $a English
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