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Flat, electronically steered lambda/...

Ellens, Nicholas Pieter Kennedy.

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Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery./
作者:	Ellens, Nicholas Pieter Kennedy.
面頁冊數:	134 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
Contained By:	Dissertation Abstracts International76-12B(E).
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3715845
ISBN:	9781321941623

Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery.
Ellens, Nicholas Pieter Kennedy.

Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery. - 134 p.

Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2015.

One of the promising applications of non-invasive focused ultrasound surgery is the treatment of women with uterine fibroids. Without any incision, fibroids can be thermally ablated in an outpatient procedure allowing patients to return to normal activity within two days.

ISBN: 9781321941623Subjects--Topical Terms:

3172799
Medical imaging.

Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery.
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245 1 0 $a Flat, electronically steered lambda/2-spaced phased arrays for focused ultrasound surgery.
300 $a 134 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
500 $a Adviser: Kullervo Hynynen.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2015.
520 $a One of the promising applications of non-invasive focused ultrasound surgery is the treatment of women with uterine fibroids. Without any incision, fibroids can be thermally ablated in an outpatient procedure allowing patients to return to normal activity within two days.
520 $a Despite its benefits and potential, the adoption of focused ultrasound surgery has been slow. Current applications of the technique are slow, exclude many women for physiological reasons, and rely on expensive MR-guidance. This thesis describes the development of a new type of focused ultrasound therapy array designed to reduce treatment time consisting of elements with half-wavelength spacing arranged in a flat array. Using simulations, this thesis will discuss the benefits and consequences of sparse phased arrays (a common technique to reduce complexity), and explore the ability of a flat, half-wavelength-spaced phased array to ablate fibroids efficiently and safely. Finally, preliminary feasibility results with a device prototype will be presented in vitro and in vivo..
520 $a The first simulation study presented here compares flat phased arrays with half-wavelength inter-element spacing with randomly-spaced sparse arrays with element populations of 75%, 50%, and 25%. Though even the very sparse (and least complex) arrays were able to perform comparable ablations, it was found that they required much more power, which was preferentially deposited in the near-field of the transducer which could extend treatment time. The second simulation study claims that a half-wavelength-spaced array at 500 kHz could perform a realistic fibroid ablation as close as 40 mm from the spine without the need for any mechanical translation. Five simulated treatments were performed at an average treatment rate of 90 +/- 20 mL/hr.
520 $a Finally, this thesis reports preliminary evidence that it is feasible to construct an array of over 1000 individually-controlled elements, arranged in 64-element blocks with half-wavelength element spacing, producing acoustic powers of over 100 W. In vitro, this array was shown to be capable of steering to its edge losing only 24% to 25% of its peak pressure. Extrapolating, this prototype suggests that it is feasible to construct a 6000+ element array suitable for efficient uterine fibroid ablation.
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710 2 $a University of Toronto (Canada). $b Medical Biophysics. $3 3181600
773 0 $t Dissertation Abstracts International $g 76-12B(E).
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