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Establishment and maintenance of rod...

Ouzounov, Nikolay.

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Establishment and maintenance of rod shape by the bacterial actin homologue MreB.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Establishment and maintenance of rod shape by the bacterial actin homologue MreB./
作者:	Ouzounov, Nikolay.
面頁冊數:	174 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
標題:	Molecular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3712781
ISBN:	9781321898187

Establishment and maintenance of rod shape by the bacterial actin homologue MreB.
Ouzounov, Nikolay.

Establishment and maintenance of rod shape by the bacterial actin homologue MreB. - 174 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--Princeton University, 2015.

Bacteria have evolved a wide range of morphologies. For the majority of bacteria, the peptidoglycan (PG) cell wall denes their cell shape. Although many of the proteins responsible for synthesizing the PG cell wall are known, the mechanisms of how they are spatiotemporally regulated remains unknown. For the most part, these enzymes are hypothesized to exist in a cell wall synthesis complex. The most likely candidate for organizing this cell wall synthesis complex is the bacterial actin homologue MreB. The structure of MreB polymers and how they organize cell wall synthesis have only recently begun to be evaluated.

ISBN: 9781321898187Subjects--Topical Terms:

517296
Molecular biology.

Establishment and maintenance of rod shape by the bacterial actin homologue MreB.
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245 1 0 $a Establishment and maintenance of rod shape by the bacterial actin homologue MreB.
300 $a 174 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500 $a Adviser: Joshua W. Shaevitz.
502 $a Thesis (Ph.D.)--Princeton University, 2015.
520 $a Bacteria have evolved a wide range of morphologies. For the majority of bacteria, the peptidoglycan (PG) cell wall denes their cell shape. Although many of the proteins responsible for synthesizing the PG cell wall are known, the mechanisms of how they are spatiotemporally regulated remains unknown. For the most part, these enzymes are hypothesized to exist in a cell wall synthesis complex. The most likely candidate for organizing this cell wall synthesis complex is the bacterial actin homologue MreB. The structure of MreB polymers and how they organize cell wall synthesis have only recently begun to be evaluated.
520 $a In this work, I use a combination of novel functional uorescent protein fusion to MreB at mreB's native locus along with novel 2D and 3D cell shape analysis of uorescence images. Using these techniques I rst show that MreB has preferential membrane curvature localization and discuss how this is related to rod shape maintenance. Next I explore how MreB is necessary for rod shape establishment through the examination of growth and reversion of cell wall decient E. coli. Finally, I explore the role of MreB polymers in how bacterial cells determine their radius. This work shows the multiple functions MreB polymers play in the organization of cell wall synthesis and brings new insights into how bacteria establish and maintain their rod shape.
590 $a School code: 0181.
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650 4 $a Microbiology. $3 536250
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