語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Mathematical Modeling of Perifusion ...
~
Temamogullari, NIhal Ezgi.
FindBook
Google Book
Amazon
博客來
Mathematical Modeling of Perifusion Cell Culture Experiments.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Mathematical Modeling of Perifusion Cell Culture Experiments./
作者:
Temamogullari, NIhal Ezgi.
面頁冊數:
92 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-09(E), Section: B.
Contained By:
Dissertation Abstracts International77-09B(E).
標題:
Applied mathematics. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10099524
ISBN:
9781339635446
Mathematical Modeling of Perifusion Cell Culture Experiments.
Temamogullari, NIhal Ezgi.
Mathematical Modeling of Perifusion Cell Culture Experiments.
- 92 p.
Source: Dissertation Abstracts International, Volume: 77-09(E), Section: B.
Thesis (Ph.D.)--Duke University, 2016.
In perifusion cell cultures, the culture medium flows continuously through a chamber containing immobilized cells and the effluent is collected at the end. In our main applications, gonadotropin releasing hormone (GnRH) or oxytocin is introduced into the chamber as the input. They stimulate the cells to secrete luteinizing hormone (LH), which is collected in the effluent. To relate the effluent LH concentration to the cellular processes producing it, we develop and analyze a mathematical model consisting of coupled partial differential equations describing the intracellular signaling and the movement of substances in the cell chamber. We analyze three different data sets and give cellular mechanisms that explain the data. Our model indicates that two negative feedback loops, one fast and one slow, are needed to explain the data and we give their biological bases. We demonstrate that different LH outcomes in oxytocin and GnRH stimulations might originate from different receptor dynamics. We analyze the model to understand the influence of parameters, like the rate of the medium flow or the fraction collection time, on the experimental outcomes. We investigate how the rate of binding and dissociation of the input hormone to and from its receptor influence its movement down the chamber. Finally, we formulate and analyze simpler models that allow us to predict the distortion of a square pulse due to hormone-receptor interactions and to estimate parameters using perifusion data. We show that in the limit of high binding and dissociation the square pulse moves as a diffusing Gaussian and in this limit the biological parameters can be estimated.
ISBN: 9781339635446Subjects--Topical Terms:
2122814
Applied mathematics.
Mathematical Modeling of Perifusion Cell Culture Experiments.
LDR
:02498nmm a2200265 4500
001
2077209
005
20161114130237.5
008
170521s2016 ||||||||||||||||| ||eng d
020
$a
9781339635446
035
$a
(MiAaPQ)AAI10099524
035
$a
AAI10099524
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Temamogullari, NIhal Ezgi.
$3
3192711
245
1 0
$a
Mathematical Modeling of Perifusion Cell Culture Experiments.
300
$a
92 p.
500
$a
Source: Dissertation Abstracts International, Volume: 77-09(E), Section: B.
500
$a
Adviser: Michael C. Reed.
502
$a
Thesis (Ph.D.)--Duke University, 2016.
520
$a
In perifusion cell cultures, the culture medium flows continuously through a chamber containing immobilized cells and the effluent is collected at the end. In our main applications, gonadotropin releasing hormone (GnRH) or oxytocin is introduced into the chamber as the input. They stimulate the cells to secrete luteinizing hormone (LH), which is collected in the effluent. To relate the effluent LH concentration to the cellular processes producing it, we develop and analyze a mathematical model consisting of coupled partial differential equations describing the intracellular signaling and the movement of substances in the cell chamber. We analyze three different data sets and give cellular mechanisms that explain the data. Our model indicates that two negative feedback loops, one fast and one slow, are needed to explain the data and we give their biological bases. We demonstrate that different LH outcomes in oxytocin and GnRH stimulations might originate from different receptor dynamics. We analyze the model to understand the influence of parameters, like the rate of the medium flow or the fraction collection time, on the experimental outcomes. We investigate how the rate of binding and dissociation of the input hormone to and from its receptor influence its movement down the chamber. Finally, we formulate and analyze simpler models that allow us to predict the distortion of a square pulse due to hormone-receptor interactions and to estimate parameters using perifusion data. We show that in the limit of high binding and dissociation the square pulse moves as a diffusing Gaussian and in this limit the biological parameters can be estimated.
590
$a
School code: 0066.
650
4
$a
Applied mathematics.
$3
2122814
690
$a
0364
710
2
$a
Duke University.
$b
Mathematics.
$3
1036449
773
0
$t
Dissertation Abstracts International
$g
77-09B(E).
790
$a
0066
791
$a
Ph.D.
792
$a
2016
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10099524
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9310077
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入