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Quantifying Complex Behavioral Pheno...

Winter, Peter B.

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Quantifying Complex Behavioral Phenotypes in C. elegans .

Record Type:	Electronic resources : Monograph/item
Title/Author:	Quantifying Complex Behavioral Phenotypes in C. elegans ./
Author:	Winter, Peter B.
Description:	164 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.
Contained By:	Dissertation Abstracts International77-08B(E).
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10043987
ISBN:	9781339554402

Quantifying Complex Behavioral Phenotypes in C. elegans .
Winter, Peter B.

Quantifying Complex Behavioral Phenotypes in C. elegans . - 164 p.

Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.

Thesis (Ph.D.)--Northwestern University, 2016.

The study of C. elegans has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological responses. However, subtle behavioral phenotypes, are often difficult to measure and reproduce across experiments. As part of my dissertation work, I used experimental and computational techniques to quantify and model the dynamics of movement and reproductive behaviors. For movement behaviors, I developed a mathematical approach to correcting the uncertainty of tracking individual animals in a free-moving population, created behavioral profiles for each individual, and used a network to reveal the progression of behavioral changes in the aging process. For reproductive behaviors, I used perturbations in temperature to dissect the key processes that modify the dynamics of the C. elegans reproductive system. The primary goal of creating this set of tools and approaches was to acquire high-quality data for mathematically modeling how individuals respond to environmental stress and modify their behaviors during ageing.

ISBN: 9781339554402Subjects--Topical Terms:

522710
Biology.

Quantifying Complex Behavioral Phenotypes in C. elegans .
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100 1 $a Winter, Peter B. $3 3192654
245 1 0 $a Quantifying Complex Behavioral Phenotypes in C. elegans .
300 $a 164 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-08(E), Section: B.
500 $a Advisers: Luis A.N. Amaral; Richard I. Morimoto.
502 $a Thesis (Ph.D.)--Northwestern University, 2016.
520 $a The study of C. elegans has led to ground-breaking discoveries in gene-function, neuronal circuits, and physiological responses. However, subtle behavioral phenotypes, are often difficult to measure and reproduce across experiments. As part of my dissertation work, I used experimental and computational techniques to quantify and model the dynamics of movement and reproductive behaviors. For movement behaviors, I developed a mathematical approach to correcting the uncertainty of tracking individual animals in a free-moving population, created behavioral profiles for each individual, and used a network to reveal the progression of behavioral changes in the aging process. For reproductive behaviors, I used perturbations in temperature to dissect the key processes that modify the dynamics of the C. elegans reproductive system. The primary goal of creating this set of tools and approaches was to acquire high-quality data for mathematically modeling how individuals respond to environmental stress and modify their behaviors during ageing.
590 $a School code: 0163.
650 4 $a Biology. $3 522710
650 4 $a Behavioral sciences. $3 529833
650 4 $a Engineering. $3 586835
690 $a 0306
690 $a 0602
690 $a 0537
710 2 $a Northwestern University. $b Chemical and Biological Engineering. $3 1023594
773 0 $t Dissertation Abstracts International $g 77-08B(E).
790 $a 0163
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10043987