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Cortical Representations Are Reinsta...

Tanaka, Kazumasa.

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Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval./
作者:	Tanaka, Kazumasa.
面頁冊數:	122 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Contained By:	Dissertation Abstracts International77-04B(E).
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3737018
ISBN:	9781339260983

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.
Tanaka, Kazumasa.

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval. - 122 p.

Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2015.

The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this long-standing idea, we used modern genetic tools to monitor the activity of individual cortical neurons while simultaneously inactivating the hippocampus. Neurons that were active during context fear conditioning were tagged with the long-lasting fluorescent protein H2B-GFP and the light activated proton pump ArchT-GFP. These proteins allowed us to identify encoding neurons several days after learning and silence them with laser stimulation. When tagged CA1 cells were silenced, we found that memory retrieval was severely impaired and representations in the cortex (subiculum, entorhinal, retrosplenial, perirhinal) and the amygdala could not be reactivated. Importantly, hippocampal inactivation did not alter the total amount of activity in most brain regions. Instead, it selectively prevented neurons that were active during learning from being reactivated during retrieval. These data provide functional evidence for the assumption that the hippocampus reactivates specific memory representations during retrieval.

ISBN: 9781339260983Subjects--Topical Terms:

588700
Neurosciences.

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.
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