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Changes in nucleus accumbens core fi...

Ma, Sisi.

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Changes in nucleus accumbens core firing patterns during reward-related events.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Changes in nucleus accumbens core firing patterns during reward-related events./
作者:	Ma, Sisi.
面頁冊數:	71 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-02(E), Section: B.
Contained By:	Dissertation Abstracts International76-02B(E).
標題:	Psychobiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3643331
ISBN:	9781321308020

Changes in nucleus accumbens core firing patterns during reward-related events.
Ma, Sisi.

Changes in nucleus accumbens core firing patterns during reward-related events. - 71 p.

Source: Dissertation Abstracts International, Volume: 76-02(E), Section: B.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2014.

This item is not available from ProQuest Dissertations & Theses.

Learning is characterized by the ability to appropriately respond to external cues that predict rewarding or aversive outcomes. The nucleus accumbens is a key mediator of reward prediction and reward-related behaviors. However, it is not well understood how accumbens neurons acquire and maintain their responsiveness to these events. In the present study, 56 nucleus accumbens core neurons were electrophysiologically recorded over 10 sessions when the animals were trained in a conditioning paradigm. Changes in firing rates of core neurons were analyzed over training days during the following events: reward cue presentation, cued and non-cued approaches towards the reward, reward consumption and reward seeking. As a population, core neurons displayed an increase in firing rate in response to presentation of the reward predicting auditory cue. The latency of core activity in response to the auditory cue was significantly reduced after animals acquired the task. Increased firing rates were also observed during approach behaviors following the onset of cue, but not during spontaneous approaches to the reward delivery port in the absence of the cue. In contrast, a general decrease in firing rate was observed during cued entry into the port when animals consumed the reward, but not during non-cued entry into the port when the reward was absent. Heterogeneous activities were discovered during all reward related events (i.e. individual neurons increased or decreased firing rate from baseline with various magnitudes). Further, strong stability across training sessions was observed during reward consumption but not during other reward-related events. That is, individual core neurons consistently responded to reward consumption across training sessions, exhibiting a general inhibition. However, individual core neurons did not consistently respond to other reward related events (e.g. cue presentation and cued approach) from session to session, indicating the general neural excitation observed during these events was mediated by different neurons from session to session.

ISBN: 9781321308020Subjects--Topical Terms:

555678
Psychobiology.

Changes in nucleus accumbens core firing patterns during reward-related events.
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