語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
Examining the role of the dentate gy...
~
Kwei, Kimberly Tsu.
FindBook
Google Book
Amazon
博客來
Examining the role of the dentate gyrus in age-related cognitive decline.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Examining the role of the dentate gyrus in age-related cognitive decline./
作者:
Kwei, Kimberly Tsu.
面頁冊數:
184 p.
附註:
Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
Contained By:
Dissertation Abstracts International75-07B(E).
標題:
Aging. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3615026
ISBN:
9781303807466
Examining the role of the dentate gyrus in age-related cognitive decline.
Kwei, Kimberly Tsu.
Examining the role of the dentate gyrus in age-related cognitive decline.
- 184 p.
Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
Thesis (Ph.D.)--Icahn School of Medicine at Mount Sinai, 2014.
This item is not available from ProQuest Dissertations & Theses.
With normal aging, there can be a certain degree of cognitive decline. The determinants of cognitive decline with aging were examined by probing the function, structure and molecular profile of the dentate gyrus (DG) in a population of behaviorally characterized aged rats. We hypothesized that changes in DG functional, molecular and structural plasticity would explain differences in cognition in behaviorally characterized aged rats. This population of aged rats was separated into two subgroups, an aged, memory- intact (aged-unimpaired, AU) and an aged, memory-impaired (aged-impaired, AI) group. AU rats perform as well as young rats on a spatial memory task while AI rats perform more poorly. We set out to understand why AU rats had better spatial memory than AI rats. The simplest hypothesis is that AU rats have functional and structural synaptic properties in the DG similar to young rats, allowing maintenance of memory abilities. However, it is also possible that DG function and ultrastructure has been modified in AU rats to adapt to changes with aging. We found that DG physiology and synaptic structure in AU rats was different from that in young and AI rats, suggesting that AU rats have developed compensatory mechanisms in the DG with aging to maintain their spatial memory abilities.
ISBN: 9781303807466Subjects--Topical Terms:
543123
Aging.
Examining the role of the dentate gyrus in age-related cognitive decline.
LDR
:02290nmm a2200289 4500
001
2076270
005
20161028121055.5
008
170521s2014 ||||||||||||||||| ||eng d
020
$a
9781303807466
035
$a
(MiAaPQ)AAI3615026
035
$a
AAI3615026
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Kwei, Kimberly Tsu.
$3
3191714
245
1 0
$a
Examining the role of the dentate gyrus in age-related cognitive decline.
300
$a
184 p.
500
$a
Source: Dissertation Abstracts International, Volume: 75-07(E), Section: B.
500
$a
Advisers: John H. Morrison; Matthew Shapiro.
502
$a
Thesis (Ph.D.)--Icahn School of Medicine at Mount Sinai, 2014.
506
$a
This item is not available from ProQuest Dissertations & Theses.
520
$a
With normal aging, there can be a certain degree of cognitive decline. The determinants of cognitive decline with aging were examined by probing the function, structure and molecular profile of the dentate gyrus (DG) in a population of behaviorally characterized aged rats. We hypothesized that changes in DG functional, molecular and structural plasticity would explain differences in cognition in behaviorally characterized aged rats. This population of aged rats was separated into two subgroups, an aged, memory- intact (aged-unimpaired, AU) and an aged, memory-impaired (aged-impaired, AI) group. AU rats perform as well as young rats on a spatial memory task while AI rats perform more poorly. We set out to understand why AU rats had better spatial memory than AI rats. The simplest hypothesis is that AU rats have functional and structural synaptic properties in the DG similar to young rats, allowing maintenance of memory abilities. However, it is also possible that DG function and ultrastructure has been modified in AU rats to adapt to changes with aging. We found that DG physiology and synaptic structure in AU rats was different from that in young and AI rats, suggesting that AU rats have developed compensatory mechanisms in the DG with aging to maintain their spatial memory abilities.
590
$a
School code: 1734.
650
4
$a
Aging.
$3
543123
650
4
$a
Neurosciences.
$3
588700
690
$a
0493
690
$a
0317
710
2
$a
Icahn School of Medicine at Mount Sinai.
$b
Neurosciences.
$3
3173600
773
0
$t
Dissertation Abstracts International
$g
75-07B(E).
790
$a
1734
791
$a
Ph.D.
792
$a
2014
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3615026
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9309138
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入