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Exploring Associations of the Diathe...

Musci, Rashelle Jean.

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Exploring Associations of the Diathetic Variability in Internalizing and Externalizing Developmental Phenotypes with Genotypic Risk.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Exploring Associations of the Diathetic Variability in Internalizing and Externalizing Developmental Phenotypes with Genotypic Risk./
作者:	Musci, Rashelle Jean.
面頁冊數:	151 p.
附註:	Source: Dissertation Abstracts International, Volume: 73-10(E), Section: B.
Contained By:	Dissertation Abstracts International73-10B(E).
標題:	Developmental psychology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3511855
ISBN:	9781267400659

Exploring Associations of the Diathetic Variability in Internalizing and Externalizing Developmental Phenotypes with Genotypic Risk.
Musci, Rashelle Jean.

Exploring Associations of the Diathetic Variability in Internalizing and Externalizing Developmental Phenotypes with Genotypic Risk. - 151 p.

Source: Dissertation Abstracts International, Volume: 73-10(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2012.

This item is not available from ProQuest Dissertations & Theses.

There is mounting evidence for the critical role of genetic factors as elements of complex individual risk profiles for a range of aversive mental health outcomes across the lifespan. In this paper, I refer to developmental phenotypes as specific longitudinal phenotypes that are identified by the longitudinal structure of a particular psychological construct across childhood and adolescence. This enhanced phenotype characterization, utilizing longitudinal information on symptomatology, is used for discovering and confirming genotype associations. The longitudinal structure is defined as the breakdown of the construct into aspects that are stable and aspects that are changing throughout development. The developmental phenotypes are modeled utilizing advanced structure equation models that decompose the variance of a set of latent factors measuring a psychological construct into stable trait-like processes and changing occasion-specific processes. I demonstrate the genotype association analysis by taking a modified genome-wide approach, examining the relationship between the stable diathesis of internalizing symptoms or externalizing behaviors and a selection of single nucleotide polymorphisms (SNPs) in areas of the genome previously determined to be areas of risk. This developmentally-based approach enables a more detailed characterization of individual heterogeneity than can be achieved by using cross-sectional phenotypes defined by presence or absence of the disorder or longitudinal phenotypes defined by lifetime prevalence of the disorder or incidence of the disorder over time. Data for this study were taken from a larger prevention intervention study through the Johns Hopkins University Prevention Intervention Research Center. This prospective longitudinal cohort study examined risk behaviors and distal outcomes for an epidemiologic-based sample from the Baltimore City schools. The study began data collection in first grade, with 798 participants. Measures included self-report measures of depression and anxiety, as well as teacher report of aggression. Genetic data were collected through blood or saliva samples. I illustrate this concept of developmental phenotypes using longitudinal measures of internalizing (specifically, depression and anxiety) and externalizing (specifically, aggression) behavior symptoms across childhood and adolescence. Briefly, results found that the stable trait variable accounted for more of the variance in internalizing symptoms across development, indicating a greater influence of the internal diathesis on symptom expression. Additionally, the risk genes of interest were significantly related to the latent trait variable. These results suggest that these genes may influence the underlying vulnerability to internalizing symptoms. Similar results were found in the study of externalizing behavior across middle childhood and adolescence. The increased knowledge of the longitudinal structure of internalizing symptoms gained by these results provide useful information about the etiology of these complex symptoms, thereby informing intervention and prevention research.

ISBN: 9781267400659Subjects--Topical Terms:

516948
Developmental psychology.

Exploring Associations of the Diathetic Variability in Internalizing and Externalizing Developmental Phenotypes with Genotypic Risk.
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