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CYTOGENETIC, MOLECULAR GENETIC AND V...

CHENEVIX TRENCH, GEORGIA.

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CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME).

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME)./
作者:	CHENEVIX TRENCH, GEORGIA.
面頁冊數:	351 p.
附註:	Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 6100.
Contained By:	Dissertation Abstracts International47-01B.
標題:	Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=8602822

CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME).
CHENEVIX TRENCH, GEORGIA.

CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME). - 351 p.

Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 6100.

Thesis (Ph.D.)--Virginia Commonwealth University/Medical College of Virginia, 1985.

Lymph node biopsies were karyotyped, 'blind' to diagnosis, from 40 individuals, 39 before treatment and all classified immunohistopathologically. Thirty patients had non-Hodgkin's lymphoma (NHL), eight had reactive hyperplasia and two had uncertain diagnoses. This is the third largest cytogenetic study of NHL to be reported. Chromosome abnormalities were observed in 29/30 NHL patients. In 4 patients there was a single aberration; in 14 patients more than 5 aberrations were observed. Structural abnormalities, which involved chromosomes 1, 9, 14, 15 and 18 most often, were more common than numerical. The only rearrangement observed repeatedly was the 14;18 translocation. It was observed in 2/8 patients with follicular lymphoma and 4/16 patients with diffuse lymphoma. The most common breakpoint was at 14q32, the location of the immunoglobulin heavy chain. We noted for the first time, that the only breakpoints (observed here and elsewhere) which may be specific to a particular subtype (diffuse large cell lymphoma) are at 4q11, 4q12 and 4q21.Subjects--Topical Terms:

530508
Genetics.

CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME).
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245 1 0 $a CYTOGENETIC, MOLECULAR GENETIC AND VIROLOGICAL ASPECTS OF NON-HODGKIN'S LYMPHOMA (ONCOGENE, CANCER, CHROMOSOME).
300 $a 351 p.
500 $a Source: Dissertation Abstracts International, Volume: 47-01, Section: B, page: 6100.
502 $a Thesis (Ph.D.)--Virginia Commonwealth University/Medical College of Virginia, 1985.
520 $a Lymph node biopsies were karyotyped, 'blind' to diagnosis, from 40 individuals, 39 before treatment and all classified immunohistopathologically. Thirty patients had non-Hodgkin's lymphoma (NHL), eight had reactive hyperplasia and two had uncertain diagnoses. This is the third largest cytogenetic study of NHL to be reported. Chromosome abnormalities were observed in 29/30 NHL patients. In 4 patients there was a single aberration; in 14 patients more than 5 aberrations were observed. Structural abnormalities, which involved chromosomes 1, 9, 14, 15 and 18 most often, were more common than numerical. The only rearrangement observed repeatedly was the 14;18 translocation. It was observed in 2/8 patients with follicular lymphoma and 4/16 patients with diffuse lymphoma. The most common breakpoint was at 14q32, the location of the immunoglobulin heavy chain. We noted for the first time, that the only breakpoints (observed here and elsewhere) which may be specific to a particular subtype (diffuse large cell lymphoma) are at 4q11, 4q12 and 4q21.
520 $a Molecular genetic analyses were conducted on three groups of patients. First, clonal immunoglobulin gene rearrangements were examined in three patients with chromosome abnormalities but no definitive diagnosis of cancer. These experiments did not reveal a clonal population of cells, and hence did not confirm the possible diagnosis of lymphoma.
520 $a Second, certain patients were identified cytogenetically to be candidates for somatic rearrangements or amplification of oncogenes. Patient CI had at (3;14) involving the bands at which c-raf-1 and the immunoglobulin heavy chain are located. No evidence of a somatic rearrangement of the raf-1 gene was found but we did observe polymorphism of raf-1 which has not been reported previously. The variant allele found in patient CI was observed in a son with Burkitt's lymphoma but not in a normal daughter. In a further 15 individuals two other variants were found; one in an individual with lymphoma and a son with cancer. Four patients were examined for evidence of oncogene amplification or rearrangement with negative results.
520 $a Third, we looked for rearrangements of c-myc in 38 patients with NHL and found a somatic rearrangement in one. There was no evidence that myc had been translocated to the immunoglobulin loci.
520 $a Finally, because of unexpected monoclonality of EBV-stimulated B-cell lines, grown for control material from patients with NHL, these lines were examined for evidence of a retrovirus. Positive evidence was found with electron microscopy, and questionably positive evidence by assay of reverse transcriptase. By co-cultivation experiments with neonatal lymphocytes we could demonstrate the presence of a transmissible factor in these lines, but could not eliminate the possibility that it was simply EBV.
590 $a School code: 0442.
650 4 $a Genetics. $3 530508
650 4 $a Pathology. $3 643180
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710 2 $a Virginia Commonwealth University/Medical College of Virginia. $3 3191553
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790 $a 0442
791 $a Ph.D.
792 $a 1985
793 $a English
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