東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Time-resolved infrared and fluoresce...

Serrano, Arnaldo L.

FindBook

Google Book

Amazon

博客來

Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure./
作者:	Serrano, Arnaldo L.
面頁冊數:	199 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
Contained By:	Dissertation Abstracts International74-10B(E).
標題:	Physical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3565227
ISBN:	9781303147722

Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure.
Serrano, Arnaldo L.

Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure. - 199 p.

Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.

Thesis (Ph.D.)--University of Pennsylvania, 2013.

While the structure of a particular folded protein is a direct outcome of the underlying thermodynamics, arriving at a quantitative and predictive understanding of how this folded structure is reached nevertheless poses huge challenges. Among those challenges is the need for probes of protein folding that possess both high temporal and structural resolution. To this end, this Thesis reports studies performed on a number of model peptide and protein systems aimed at applying novel spectroscopic techniques and molecular probes to the task of acquiring highly detailed information about either the mechanism of folding or the nature of the native protein structure.

ISBN: 9781303147722Subjects--Topical Terms:

1981412
Physical chemistry.

Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure.
LDR:02327nmm a2200301 4500 001 2076074
005 20161101084232.5
008 170521s2013 ||||||||||||||||| ||eng d
020 $a 9781303147722
035 $a (MiAaPQ)AAI3565227
035 $a AAI3565227
040 $a MiAaPQ $c MiAaPQ
100 1 $a Serrano, Arnaldo L. $3 3191504
245 1 0 $a Time-resolved infrared and fluorescence spectroscopic studies of protein dynamics and structure.
300 $a 199 p.
500 $a Source: Dissertation Abstracts International, Volume: 74-10(E), Section: B.
500 $a Adviser: Feng Gai.
502 $a Thesis (Ph.D.)--University of Pennsylvania, 2013.
520 $a While the structure of a particular folded protein is a direct outcome of the underlying thermodynamics, arriving at a quantitative and predictive understanding of how this folded structure is reached nevertheless poses huge challenges. Among those challenges is the need for probes of protein folding that possess both high temporal and structural resolution. To this end, this Thesis reports studies performed on a number of model peptide and protein systems aimed at applying novel spectroscopic techniques and molecular probes to the task of acquiring highly detailed information about either the mechanism of folding or the nature of the native protein structure.
520 $a The earlier chapters of this Thesis present studies on the utility of the artificial amino-acid p-cyanophenylalanine as a time-resolved fluorescence and energy-transfer probe of local protein structure. Application of this probe to the villin headpiece subdomain revealed new details about the native state ensemble of this mini-protein.
520 $a The later chapters report the findings of a number of time-resolved laser temperature-jump experiments on model helical peptides as well as on the mini-protein Trp-Cage. These experiments provide benchmarks for some of the elementary kinetic events of helix formation for the former and detailed insight into the folding mechanism of one of the fastest folding proteins known to date for the latter.
590 $a School code: 0175.
650 4 $a Physical chemistry. $3 1981412
650 4 $a Biophysics. $3 518360
690 $a 0494
690 $a 0786
710 2 $a University of Pennsylvania. $b Chemistry. $3 2096482
773 0 $t Dissertation Abstracts International $g 74-10B(E).
790 $a 0175
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3565227