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Amygdala processing of the formation...

Tye, Kay M.

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Amygdala processing of the formation and retrieval of cue -reward associations.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Amygdala processing of the formation and retrieval of cue -reward associations./
作者:	Tye, Kay M.
面頁冊數:	163 p.
附註:	Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5241.
Contained By:	Dissertation Abstracts International69-09B.
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3324587
ISBN:	9780549757696

Amygdala processing of the formation and retrieval of cue -reward associations.
Tye, Kay M.

Amygdala processing of the formation and retrieval of cue -reward associations. - 163 p.

Source: Dissertation Abstracts International, Volume: 69-09, Section: B, page: 5241.

Thesis (Ph.D.)--University of California, San Francisco, 2008.

This thesis examines the neural changes that contribute to the formation, storage, retrieval and extinction of a learned association between a stimulus and a reward. A number of questions were answered in this thesis to provide insight upon the neural substrates of several goal-directed behaviors: What neural changes mediate the initial formation of an associative memory between a stimulus and a reward? What are the synaptic changes that correspond to the development of a change in task-relevant neuronal firing? What is the mechanism of these synaptic changes, and do they have a causal relationship? How are complex emotions such as frustration represented in the brain? How are reward-associated cues endowed with the power to guide goal-directed behaviors in the absence of primary rewards? Here I show that behavior improves with the rapid recruitment of amygdala neurons to the ensemble encoding a reward-predictive cue, and that this change is mediated by the rapid strengthening of thalamic synapses onto amygdala neurons by a postsynaptic increase of AMPAR-mediated currents. These synaptic changes, in addition to the acquisition of the task, depend on NMDAR activation. Amygdala neurons that store the memory of a reward are activated when an animal compares the expected reward with the unexpected omission of that reward. Finally, distinct populations of amygdala neurons reflect the motivating and reinforcing properties of a cue endowed with the emotional significance to guide behavior.

ISBN: 9780549757696Subjects--Topical Terms:

588700
Neurosciences.

Amygdala processing of the formation and retrieval of cue -reward associations.
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