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The Molecular Epidemiology of Dioxin...

Ruestow, Peter.

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The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers./
作者:	Ruestow, Peter.
面頁冊數:	137 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
Contained By:	Dissertation Abstracts International77-07B(E).
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10003313
ISBN:	9781339424873

The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers.
Ruestow, Peter.

The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers. - 137 p.

Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.

Thesis (Ph.D.)--University of Illinois at Chicago, 2015.

Background:

ISBN: 9781339424873Subjects--Topical Terms:

568544
Epidemiology.

The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers.
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100 1 $a Ruestow, Peter. $3 3191405
245 1 4 $a The Molecular Epidemiology of Dioxin Exposure in Former Chemical Workers.
300 $a 137 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
502 $a Thesis (Ph.D.)--University of Illinois at Chicago, 2015.
520 $a Background:
520 $a Dioxins, a class of toxic and persistent chemical compounds, are ubiquitous in the environment. This dissertation presents the results of three studies that share the major aim of characterizing some of the mechanistic factors through which dioxins exert their toxic effects in humans, using observational data. The first investigated the association with a chromosomal aberration that may mediate development of Non-Hodgkin's Lymphoma (NHL). The second evaluated the potential antagonistic behavior of non-dioxin-like polychlorinated biphenyls on dioxin activity. The third was designed to better understand chloracne susceptibility in exposed persons.
520 $a Methods:
520 $a A large international multidisciplinary research team enrolled, surveyed, and examined two cohorts of Eastern European subjects. One was composed of chemical factory workers occupationally exposed to dioxins. The other was composed of residents from a nearby city without known dioxin exposure. Additionally, the relationship between dioxin exposure and gene expression in a subsample of the two cohorts was investigated.
520 $a Results:
520 $a The first study demonstrated a significant association between background serum levels of dioxin-like polychlorinated biphenyl 126 and chromosomal translocation t(14;18) frequency in the population-based cohort, and this relationship was modified by smoking habit. In the second study, expression of the aryl hydrocarbon receptor was significantly associated with serum dioxin levels, and non-dioxin-like polychlorinated biphenyl 153 was shown to have an antagonistic effect on this dioxin-induced expression. The third study showed a much higher prevalence of smoking in those who developed chloracne versus those who did not in the occupationally exposed cohort.
520 $a Conclusions:
520 $a These findings suggest a biologically plausible mechanism for increased risk of NHL. Additionally, this is the first time that the interaction between dioxin-like and non-dioxin-like compounds has been reported in a human observational study. Finally, these findings may help to explain why only some of those with dioxin exposure seem more likely to develop chloracne. Taken together, the results of these studies have important implications for risk assessment of exposure to dioxins and dioxin-like compounds. Furthermore, these findings suggest that dioxin toxicity in humans may be significantly altered by avoidance or cessation of smoking, a modifiable behavior.
590 $a School code: 0799.
650 4 $a Epidemiology. $3 568544
690 $a 0766
710 2 $a University of Illinois at Chicago. $b Environmental and Occupational Health Sciences. $3 3191406
773 0 $t Dissertation Abstracts International $g 77-07B(E).
790 $a 0799
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10003313