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Tailorable Release of Small Molecule...

Cao, Jing.

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Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix./
作者:	Cao, Jing.
面頁冊數:	173 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.
Contained By:	Dissertation Abstracts International75-10B(E).
標題:	Nanotechnology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3584289
ISBN:	9781303998003

Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix.
Cao, Jing.

Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix. - 173 p.

Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.

Thesis (Ph.D.)--North Carolina State University, 2014.

We have engineered Red clover necrotic mosaic virus (RCNMV) derived plant viral nanoparticles (PVNs) within a fibrous matrix to optimize its application for delivery and controlled release of active ingredients. RCNMV's structure and unique response to divalent cation depletion and re-addition enables the infusion of small molecules into its viral capsid through a pore formation mechanism. While this PVN technology shows a potential use in nano-scale therapeutic drug delivery, its inherent molecular dynamics to environmental stimuli places a constraint on its application and functionality as a vehicle for tailorable release of loading cargo. In this study, we enhance the understanding of the PVN technology by elucidating its mechanism for loading and triggered release of doxorubicin (Dox), a chemotherapeutic drug for breast cancer. Of critical importance is the methodology for manipulation of Dox's loading capacity and its binding location on either the exterior or interior of the virion capsid. The ability to control the active ingredient binding location provides an additional approach of tunable release from the PVN delivery vehicle besides its inherent pH- and ion- responsive release of loading cargo.

ISBN: 9781303998003Subjects--Topical Terms:

526235
Nanotechnology.

Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix.
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100 1 $a Cao, Jing. $3 1917670
245 1 0 $a Tailorable Release of Small Molecules Utilizing Plant Viral Nanoparticles and Fibrous Matrix.
300 $a 173 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-10(E), Section: B.
500 $a Advisers: Julie A. Willoughby; Saad Khan.
502 $a Thesis (Ph.D.)--North Carolina State University, 2014.
520 $a We have engineered Red clover necrotic mosaic virus (RCNMV) derived plant viral nanoparticles (PVNs) within a fibrous matrix to optimize its application for delivery and controlled release of active ingredients. RCNMV's structure and unique response to divalent cation depletion and re-addition enables the infusion of small molecules into its viral capsid through a pore formation mechanism. While this PVN technology shows a potential use in nano-scale therapeutic drug delivery, its inherent molecular dynamics to environmental stimuli places a constraint on its application and functionality as a vehicle for tailorable release of loading cargo. In this study, we enhance the understanding of the PVN technology by elucidating its mechanism for loading and triggered release of doxorubicin (Dox), a chemotherapeutic drug for breast cancer. Of critical importance is the methodology for manipulation of Dox's loading capacity and its binding location on either the exterior or interior of the virion capsid. The ability to control the active ingredient binding location provides an additional approach of tunable release from the PVN delivery vehicle besides its inherent pH- and ion- responsive release of loading cargo.
520 $a The efficacious and controlled release strategy for agricultural active ingredients, such as nematicides, is also a large social need right now. Crop infestation of plant parasite nematodes causes in excess of $157 billion in worldwide crop damage annually. If an effective control strategy for these pests could be developed, it is estimated that the current market for effective nematicides is between $700 million and $1 billion each year worldwide. In this study, we report on the utilization of PVN technology to encapsulate the biological nematicide, abamectin (Abm), within the PVN's interior capsid (PVNAbm). Creating PVNAbm addresses Abm's issues of soil immobility while rendering a controlled release strategy for its bioavailability to root knot nematodes (RKNs). The encapsulation by a PVN carrier also improves the stability of Abm as well as further isolates its toxicity from the end-user. We used this crop treatment methodology by applying PVNAbm to tomato seedlings that we artificially inoculated with RKN M. hapla. We show that the zone of root protection from RKN that is limited by free Abm in the soil is improved; contributing to the enhanced nematicide performance in crop protection.
520 $a Lignocellulosic materials were engineered as a supporting fibrous matrix to distribute PVNAbm or free Abm in a field-deployable matrix. This enables a cost-effective, environmentally sound method for simply applying the crop protection agent at the point of seed planting. An approach designed to be useful for smallholder farmers in East Africa regions. In addition, the chemical and physical properties of the fibrous matrix provide an additional release mechanism for transporting active ingredients. Varying the source of lignocellulosic materials and pre-processing pulping methods results in fibrous matrices with distinct difference in their cargo release rate for both Abm in free form or encapsulated in PVN. The relative slow and sustainable cargo release is achieved by incorporating with banana lignocellulosic matrix that contains higher amount of lignin in the bulk, which enables a delayed and long-term activity against nematodes. On the other hand, the decreased amount of lignin in abaca lignocellulosic matrix give rise to a burst release of loaded Abm or PVNAbm, which exhibits a simultaneous effectiveness against nematodes, but compromises the crop protection around the growing plant in the long-term.
520 $a In summary, our work demonstrates the potential for utilization of a PVN-matrix hybrid system for active ingredient delivery, where manipulating the properties and interactions among these components, active ingredient, PVN and fibrous matrix, provides unlimited possibilities for the tailorable release of active ingredients in any given application.
590 $a School code: 0155.
650 4 $a Nanotechnology. $3 526235
650 4 $a Materials science. $3 543314
650 4 $a Plant pathology. $3 3174872
690 $a 0652
690 $a 0794
690 $a 0480
710 2 $a North Carolina State University. $b Fiber and Polymer Science. $3 2091959
773 0 $t Dissertation Abstracts International $g 75-10B(E).
790 $a 0155
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3584289