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Prediction of coronary heart disease...

Gander, Jennifer Carol.

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Prediction of coronary heart disease within the Aerobics Center Longitudinal Study population.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Prediction of coronary heart disease within the Aerobics Center Longitudinal Study population./
作者:	Gander, Jennifer Carol.
面頁冊數:	171 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
Contained By:	Dissertation Abstracts International76-01B(E).
標題:	Epidemiology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3634828
ISBN:	9781321155372

Prediction of coronary heart disease within the Aerobics Center Longitudinal Study population.
Gander, Jennifer Carol.

Prediction of coronary heart disease within the Aerobics Center Longitudinal Study population. - 171 p.

Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.

Thesis (Ph.D.)--University of South Carolina, 2014.

Background: The Framingham Risk Score (FRS) includes a limited set of risk factors and does not include cardiorespiratory fitness (CRF), which has been shown to have a strong protective effect on coronary heart disease (CHD). We aim to examine the association of CRF on 10-year risk of CHD while controlling for individuals' FRS. Methods and Results: The study included 29,854 men from the Aerobics Center Longitudinal Study (ACLS) who received a baseline examination from 1979 to 2002. CHD events included self-reported myocardial infarction or revascularization, or CHD death. Multivariable survival analysis investigated the association between CRF, FRS, and CHD. CRF was analyzed as both a continuous and categorical variable. The population was stratified by 'low' and 'moderate or high' risk for CHD to test for interaction between CRF and FRS. Men with incident CHD were older (mean age = 51.6 years), had an average maximally achieved fitness of 10.9 metabolic equivalent of task (METs), and were more likely to have 'moderate or high' 10-year CHD risk, compared to men without incident CHD (p-value<0.001). CRF, defined as maximal METs, showed a 20% lower risk of CHD (HR=0.80, 95% CI 0.77, 0.83) for each 1 unit MET increase. Men within the 'low' 10-year CHD risk strata and high (HR=0.62, 95% CI 0.45, 0.84) CRF had a lower CHD risk compared with men in the same strata, but with low CRF (p-value <0.001). Conclusion: Clinicians should emphasize the promotion of physical activity to improve CRF to reduce CHD risk, even in patients with otherwise low CHD risk.

ISBN: 9781321155372Subjects--Topical Terms:

568544
Epidemiology.

Prediction of coronary heart disease within the Aerobics Center Longitudinal Study population.
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