東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Bayesian statistical analysis in a p...

Li, Shiansong.

FindBook

Google Book

Amazon

博客來

Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia./
作者:	Li, Shiansong.
面頁冊數:	166 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
Contained By:	Dissertation Abstracts International75-09B(E).
標題:	Statistics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3585002
ISBN:	9781321061703

Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia.
Li, Shiansong.

Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia. - 166 p.

Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.

Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey, 2014.

This item is not available from ProQuest Dissertations & Theses.

Bayesian approaches have been widely used in designing, monitoring and analyzing clinical studies in recent years. We utilize Bayesian parametric and non-parametric statistical methods in interim monitoring and decision-making for a phase II dose-finding trial with survival endpoint. The objective of the clinical trial is to find an optimal treatment schedule at the end of the study for planning future studies, using Bayesian decision rules. The primary efficacy outcome is time to progression. Binomial-Beta model and Exponential-Gamma model are included in parametric methods. Non-parametric methods include Bayesian life-table, Beta process model, Dirichlet process model and Gibbs sampling. Simulations are conducted for each of the statistical methods under 9 different scenarios including truncated exponential entry time, and the probability of a treatment-schedule being chosen is calculated based on 1,000 simulation studies. Finally, these different statistical methods are used to find optimal treatment-schedule among 3 arms in the phase II CLL clinical trial using the most recent unblinded data.

ISBN: 9781321061703Subjects--Topical Terms:

517247
Statistics.

Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia.
LDR:02243nmm a2200301 4500 001 2065285
005 20151130143842.5
008 170521s2014 ||||||||||||||||| ||eng d
020 $a 9781321061703
035 $a (MiAaPQ)AAI3585002
035 $a AAI3585002
040 $a MiAaPQ $c MiAaPQ
100 1 $a Li, Shiansong. $3 3179968
245 1 0 $a Bayesian statistical analysis in a phase II dose-finding trial with survival endpoint in patients with B-cell chronic lymphocytic leukemia.
300 $a 166 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-09(E), Section: B.
500 $a Adviser: Weichung Joe Shih.
502 $a Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Bayesian approaches have been widely used in designing, monitoring and analyzing clinical studies in recent years. We utilize Bayesian parametric and non-parametric statistical methods in interim monitoring and decision-making for a phase II dose-finding trial with survival endpoint. The objective of the clinical trial is to find an optimal treatment schedule at the end of the study for planning future studies, using Bayesian decision rules. The primary efficacy outcome is time to progression. Binomial-Beta model and Exponential-Gamma model are included in parametric methods. Non-parametric methods include Bayesian life-table, Beta process model, Dirichlet process model and Gibbs sampling. Simulations are conducted for each of the statistical methods under 9 different scenarios including truncated exponential entry time, and the probability of a treatment-schedule being chosen is calculated based on 1,000 simulation studies. Finally, these different statistical methods are used to find optimal treatment-schedule among 3 arms in the phase II CLL clinical trial using the most recent unblinded data.
590 $a School code: 0801.
650 4 $a Statistics. $3 517247
650 4 $a Medicine. $3 641104
650 4 $a Public health. $3 534748
690 $a 0463
690 $a 0564
690 $a 0573
710 2 $a Rutgers The State University of New Jersey - New Brunswick and University of Medicine and Dentistry of New Jersey. $3 1023857
773 0 $t Dissertation Abstracts International $g 75-09B(E).
790 $a 0801
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3585002