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The influence of aging on oocyte qua...

Trull, Krystal.

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The influence of aging on oocyte quality and the importance of mitochondria.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The influence of aging on oocyte quality and the importance of mitochondria./
作者:	Trull, Krystal.
面頁冊數:	93 p.
附註:	Source: Masters Abstracts International, Volume: 53-05.
Contained By:	Masters Abstracts International53-05(E).
標題:	Cellular biology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1563539
ISBN:	9781321130317

The influence of aging on oocyte quality and the importance of mitochondria.
Trull, Krystal.

The influence of aging on oocyte quality and the importance of mitochondria. - 93 p.

Source: Masters Abstracts International, Volume: 53-05.

Thesis (M.S.)--Northeastern University, 2014.

Female fertility peaks at 25 years of age, yet many women put off having children until much later in life (Nybo Andersen et al. 2000; Hook 1981; Hamilton et al. 2013). Age is a major determining factor in pregnancy outcomes and increased maternal age is correlated with increased chances of aneuploidy and miscarriage (Robinson et al. 2001; Benadiva et al. 1996; Battaglia et al. 1996). When older women encounter difficulties with having a successful pregnancy, it is often due to poor oocyte quality as a result of mitochondrial dysfunction (Eichenlaub-Ritter et al. 2011; Bentov et al. 2010; Jansen & Burton 2004). Mitochondria are the energy-producing organelles of the cell and are important in producing adenosine triphosphate (ATP) to meet the high energy demands of the oocyte. Mitochondria have their own DNA (mtDNA) inherited maternally that encodes proteins necessary for oxidative phosphorylation and subsequent ATP production. Along with ATP, mitochondria also produce harmful reactive oxygen species (ROS) at a low, but significant rate (Takeo et al. 2013; Parsons et al. 1997). With natural aging, mtDNA damages due to ROS can accumulate and disrupt normal cell function and ATP production. Without adequate ATP supply, oocytes fail to fertilize, implant, or develop properly during pregnancy. This eventual decline of oocyte quality occurs with natural aging, but decreased fertility is also observed in diabetes and other metabolic disorders (Moley et al. 1991; Sadler et al. 1988). As the number of women and couples seeking fertility treatments increases, it is important to understand why pregnancy fails. In this thesis, oocyte quality and its decline with maternal age are discussed, with a focus on the effects of mitochondrial dysfunction. Factors and disorders affecting proper mitochondrial function are introduced, and methods of both improving and preserving oocyte quality are reviewed.

ISBN: 9781321130317Subjects--Topical Terms:

3172791
Cellular biology.

The influence of aging on oocyte quality and the importance of mitochondria.
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