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The impact of aging and exercise tra...

Chen, Bei.

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The impact of aging and exercise training on the coronary circulation.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The impact of aging and exercise training on the coronary circulation./
作者:	Chen, Bei.
面頁冊數:	121 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.
Contained By:	Dissertation Abstracts International76-08B(E).
標題:	Aging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3691325
ISBN:	9781321644425

The impact of aging and exercise training on the coronary circulation.
Chen, Bei.

The impact of aging and exercise training on the coronary circulation. - 121 p.

Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.

Thesis (Ph.D.)--University of Florida, 2014.

The risk for diastolic heart failure increases with advancing age. Regular physical exercise training prevents and/or ameliorates the progression of age-related diastolic dysfunction; however, the underlying mechanisms have not been identified. This dissertation focuses on the impact of age and exercise training on the coronary circulation and microvascular function, which may contribute to altered diastolic function. Doppler analysis showed that age impaired cardiac diastolic function and latelife exercise training improved diastolic function in rats. Blood flow into the endocardium and epicardium was significantly blunted in aged hearts at resting and during exercise. Late-life exercise training increased endocaridial and epicardial flow at rest and during exercise. Age impaired contractile function and exercise training attenuated age-related contractile dysfunction of coronary resistance arterioles. Our findings suggest age impairs diastolic function by blunting coronary blood flow that is a result of contractile dysfunction in coronary arterioles. Exercise training initiated in old age ameliorates agerelated diastolic dysfunction by attenuating coronary arteriolar contractile dysfuntion and improving resting and hyperemic blood flow to left ventricular free wall. We also demonstrated that reduced circulating adiponectin and adenosine monophosphate activated kinase contributed to age-related impairments of contractile function and vascular smooth muscle function in coronary microvasculature; whereas exercise training increased circulating adiponectin concerntration. Circulating adiponectin levels decreased with age and increased after exercise training in both young and old rats. Age increased and exercise training attenuated synthetic markers of vascular smooth muscle cells in coronary resistance arteries. Age reduced levels of adenosine monophosphate-activated kinase and contractile proteins, smooth muscle myosin 1 and smooth muscle myosin 2; whereas age increased total levels and phosphorylation of ribosomal protein S6. Exercise training improved smooth muscle myosin 1, total and phosphorylated ribosomal protein S6 levels in arterioles of old rats. Wall thickness was increased with age. Late-life exercise induced structural changes in vascular smooth muscle, including reduced wall thickness and increased extracellular elastin content.

ISBN: 9781321644425Subjects--Topical Terms:

543123
Aging.

The impact of aging and exercise training on the coronary circulation.
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