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The Paternal Age Effect: A Prelimina...

Gunter, Andrew T.

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The Paternal Age Effect: A Preliminary Study of Current Challenges for Prenatal Genetics Care.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	The Paternal Age Effect: A Preliminary Study of Current Challenges for Prenatal Genetics Care./
作者:	Gunter, Andrew T.
面頁冊數:	67 p.
附註:	Source: Masters Abstracts International, Volume: 53-01.
Contained By:	Masters Abstracts International53-01(E).
標題:	Genetics. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1556390
ISBN:	9781303916748

The Paternal Age Effect: A Preliminary Study of Current Challenges for Prenatal Genetics Care.
Gunter, Andrew T.

The Paternal Age Effect: A Preliminary Study of Current Challenges for Prenatal Genetics Care. - 67 p.

Source: Masters Abstracts International, Volume: 53-01.

Thesis (M.S.)--University of South Carolina, 2014.

Advanced paternal age (APA) is related to various genetic conditions, behavioral disorders, and adverse pregnancy outcomes. Since the publication of ACMG's practice guidelines on APA in 2008, much has been learned about the causes of paternal age effect (PAE) mutations and their clinical implications. However, no guidelines exist to refer these high-risk pregnancies to prenatal genetics care, nor are effective screening techniques presently available. As such, many patients are not fully-informed about the risks to their pregnancies due to possible APA effects, and neither are are the men who have fathered these pregnancies. Our findings support that limited APA principles are being disseminated into the general population. Additionally, prenatal patients of advanced maternal age (AMA) and their partners favor the fathers of pregnancies as important decision makers, second only to the mothers. Based on current knowledge of APA risks and molecular mechanisms, as well as our study findings, we support a collaborative effort to address the shortcomings of current prenatal genetic counseling procedure in its discussions of APA. The approach to rectify this discrepancy in prenatal genetic counseling should include a revisit of the 2008 ACMG guidelines concerning APA as well as research efforts directed toward the future goal of providing inclusive genetic counseling for men of APA and the pregnancies they father.

ISBN: 9781303916748Subjects--Topical Terms:

530508
Genetics.

The Paternal Age Effect: A Preliminary Study of Current Challenges for Prenatal Genetics Care.
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