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Investigation of angiogenic effects ...

Watters, Richard Jeffrey.

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Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model./
作者:	Watters, Richard Jeffrey.
面頁冊數:	73 p.
附註:	Source: Masters Abstracts International, Volume: 53-04.
Contained By:	Masters Abstracts International53-04(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1561278
ISBN:	9781321062663

Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model.
Watters, Richard Jeffrey.

Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model. - 73 p.

Source: Masters Abstracts International, Volume: 53-04.

Thesis (M.S.)--Missouri University of Science and Technology, 2014.

This item must not be sold to any third party vendors.

The primary objective of this research project was to evaluate the effects of three different compositions of bioactive glass microfibers (45S5, 13-93B3, and 13-93B3Cu) and bioactive glass beads (13-93, 13-93B3, and 13-93B3Cu) on angiogenesis in subcutaneous tissue in the SKH1 `hairless' mouse. Microvascular responses to the bioactive glass implants were investigated via three experimental approaches: noninvasive vital imaging of microvasculature in dorsal skin windows; quantitative histomorphometry of microvascular densities; and quantitative PCR measurements of mRNA expression of pro-angiogenic cytokines VEGF and FGF-2. The live imaging of dorsal skin window preparations in the hairless SKH1 showed the formation of a halo-like structure infused with vessels in soft tissue surrounding borate-based 13-93B3 and 13-93B3Cu glass beads two weeks after implantation. This response was not observed around silicate-based 13-93 glass beads. Quantitative histomorphometry of tissue implanted with 45S5, 13-93B3, and 13-93B3Cu glass microfiber plugs revealed microvascular densities that were 1.6-, 2.3-, and 2.7-fold higher, respectively compared to the sham control tissues whereas the 13-93, 13-93B3, and 13-93B3Cu glass beads produced a 1.3-, 1.6-, and 2.5-fold increase, respectively, compared to the sham control. Quantitative PCR measurements indicate a marginally significant increase in expression of VEGF mRNA in skin tissues with 13-93B3Cu. This latter outcome supports the project hypothesis that 13-93B3Cu glass induces VEGF expression followed by neovascularization, a key process of wound healing.

ISBN: 9781321062663Subjects--Topical Terms:

535387
Biomedical engineering.

Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model.
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245 1 0 $a Investigation of angiogenic effects of bioactive borate glass microfibers and beads in a rodent model.
300 $a 73 p.
500 $a Source: Masters Abstracts International, Volume: 53-04.
500 $a Adviser: Roger F. Brown.
502 $a Thesis (M.S.)--Missouri University of Science and Technology, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a The primary objective of this research project was to evaluate the effects of three different compositions of bioactive glass microfibers (45S5, 13-93B3, and 13-93B3Cu) and bioactive glass beads (13-93, 13-93B3, and 13-93B3Cu) on angiogenesis in subcutaneous tissue in the SKH1 `hairless' mouse. Microvascular responses to the bioactive glass implants were investigated via three experimental approaches: noninvasive vital imaging of microvasculature in dorsal skin windows; quantitative histomorphometry of microvascular densities; and quantitative PCR measurements of mRNA expression of pro-angiogenic cytokines VEGF and FGF-2. The live imaging of dorsal skin window preparations in the hairless SKH1 showed the formation of a halo-like structure infused with vessels in soft tissue surrounding borate-based 13-93B3 and 13-93B3Cu glass beads two weeks after implantation. This response was not observed around silicate-based 13-93 glass beads. Quantitative histomorphometry of tissue implanted with 45S5, 13-93B3, and 13-93B3Cu glass microfiber plugs revealed microvascular densities that were 1.6-, 2.3-, and 2.7-fold higher, respectively compared to the sham control tissues whereas the 13-93, 13-93B3, and 13-93B3Cu glass beads produced a 1.3-, 1.6-, and 2.5-fold increase, respectively, compared to the sham control. Quantitative PCR measurements indicate a marginally significant increase in expression of VEGF mRNA in skin tissues with 13-93B3Cu. This latter outcome supports the project hypothesis that 13-93B3Cu glass induces VEGF expression followed by neovascularization, a key process of wound healing.
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