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Electrochemical Assessment of Nanopa...

Ozel, Rifat Emrah.

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Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress./
作者:	Ozel, Rifat Emrah.
面頁冊數:	173 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
Contained By:	Dissertation Abstracts International75-08B(E).
標題:	Analytical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3618797
ISBN:	9781303873058

Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress.
Ozel, Rifat Emrah.

Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress. - 173 p.

Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.

Thesis (Ph.D.)--Clarkson University, 2014.

This item must not be sold to any third party vendors.

The increased use of engineered nanoparticles (NPs) in manufacturing and consumer products raises concerns about their potential environmental and health effects on the ecosystem and living organisms. Understanding the interaction of NPs with biological systems and assessing how exposure to NPs affects biological and chemical mechanisms in living systems is of critical importance. Although there are several toxicological studies describing the qualitative effects of NPs exposure, their impact on the physiology of living organisms, especially at low concentrations exposure remains largely unknown. This thesis reports on the first use of electrochemical microsensors to quantitatively monitor localized physiological changes at organ level as a result of NPs exposure. It demonstrates that electrochemical microsensors can provide real-time in vivo measurement capabilities of various markers for nanotoxicity assessment with high sensitivity and selectivity while providing high spatial and temporal resolution.

ISBN: 9781303873058Subjects--Topical Terms:

3168300
Analytical chemistry.

Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress.
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245 1 0 $a Electrochemical Assessment of Nanoparticle-Induced Organ Dysfunction and Oxidative Stress.
300 $a 173 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
500 $a Adviser: Silvana E. Andreescu.
502 $a Thesis (Ph.D.)--Clarkson University, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a The increased use of engineered nanoparticles (NPs) in manufacturing and consumer products raises concerns about their potential environmental and health effects on the ecosystem and living organisms. Understanding the interaction of NPs with biological systems and assessing how exposure to NPs affects biological and chemical mechanisms in living systems is of critical importance. Although there are several toxicological studies describing the qualitative effects of NPs exposure, their impact on the physiology of living organisms, especially at low concentrations exposure remains largely unknown. This thesis reports on the first use of electrochemical microsensors to quantitatively monitor localized physiological changes at organ level as a result of NPs exposure. It demonstrates that electrochemical microsensors can provide real-time in vivo measurement capabilities of various markers for nanotoxicity assessment with high sensitivity and selectivity while providing high spatial and temporal resolution.
520 $a The thesis describes fabrication, characterization and in vivo use of several electrochemical microsensors for the detection of physiological changes of serotonin (5-HT) and nitric oxide (NO) and the use of these probes for investigating mechanisms related to NPs exposure in zebrafish embryos. The information acquired with this newly introduced method, combined with conventional toxicological assays, has been used to obtain mechanistic information on the nanotoxic response including oxidative stress, inflammation and organ dysfunction in intact zebrafish embryos exposed to several types of metal and metal oxide NPs. Mechanistically, results in this thesis show evidence that environmental exposure to NPs might affect the physiology of the developing intestine in characteristic ways that is highly dependent on the type, composition, exposure time and concentration of NPs. This information could be used to predict long term physiological effects of NPs exposure in living organisms.
520 $a The outcome of the thesis is the development of a new methodology for nanotechnology risk assessment, as well as the mechanistic information derived indicating physiological alterations of the 5-HT and NO levels within embryonic zebrafish intestine, and potentially of other intestinal systems, as a result of NPs exposure.
520 $a Overview of the Thesis. Chapter 1 provides a general overview of nanotechnology and an introduction to the current state-of-knowledge on nanoparticle toxicity [1]. Chapters 2, 3 and 4 focus on assessing NPs effects on intestinal 5-HT. Chapter 2 describes the development and characterization of a carbon fiber microsensor for the detection of 5-HT with an example of in vivo application for monitoring 5-HT levels in the intestine of zebrafish embryos [2, 3]. Chapters 3 and 4 present studies of the effect of NPs exposure on the physiological 5-HT levels within the intestine of zebrafish embryos monitored using the 5-HT specific microsensor discussed in Chapter 2 [4]. Chapter 3 focusses on the effect and reactivity of CeO2 against 5-HT while Chapter 4 assesses the effect of CuO and Ni NPs exposure to developing embryos. Chapter 5 demonstrates the development and characterization of a NO microsensor and its application for the assessment of changes in physiological NO levels in the intestine of zebrafish embryos upon exposure to CeO 2 and CuO NPs [5].
590 $a School code: 0049.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Environmental science. $3 677245
650 4 $a Toxicology. $3 556884
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710 2 $a Clarkson University. $b Chemistry. $3 3177158
773 0 $t Dissertation Abstracts International $g 75-08B(E).
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791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3618797