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A multi-mode atmospheric ambient ion...

Jariwala, Freneil Bakul.

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A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry./
作者:	Jariwala, Freneil Bakul.
面頁冊數:	331 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
Contained By:	Dissertation Abstracts International76-01B(E).
標題:	Analytical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3636039
ISBN:	9781321174427

A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry.
Jariwala, Freneil Bakul.

A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry. - 331 p.

Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.

Thesis (Ph.D.)--Stevens Institute of Technology, 2014.

This item must not be sold to any third party vendors.

Mass spectrometric ionization methods that operate under ambient conditions and require minimal or no sample preparation have revolutionized the field of mass spectrometry over the past decade. However, many of these techniques require dedicated hardware and are often limited towards the detection of a specific class of compounds. The research reported in this dissertation focuses on the development and applications of multi-mode atmospheric ambient ionization source, which can be utilized towards the analysis of a wide range of compounds. The multi-mode ionization source can be operated under traditional electrospray ionization (ESI), atmospheric-pressure chemical ionization (APCI), and desorption electrospray ionization (DESI) modes, as well as the proprietary Stevens developed techniques desorption ionization by charge exchange (DICE) and helium plasma ionization (HePI). In the HePI technique, a non-thermal micro-plasma, generated by passing helium through a metal capillary held at high voltage, is used to ionize volatile organic compounds. Fundamental studies on the impact of helium flow rate, capillary position and voltage, and desorption gas flow rate and temperature on plasma formation and analyte-ion formation are reported. Furthermore, detection of a variety of compounds, including peptides/proteins, polymers, and small- molecule nonpolar and polar analytes, is demonstrated.

ISBN: 9781321174427Subjects--Topical Terms:

3168300
Analytical chemistry.

A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry.
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245 1 2 $a A multi-mode atmospheric ambient ionization source and its use for ion fragmentation investigations by mass spectrometry.
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500 $a Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
500 $a Adviser: Athula B. Attygalle.
502 $a Thesis (Ph.D.)--Stevens Institute of Technology, 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Mass spectrometric ionization methods that operate under ambient conditions and require minimal or no sample preparation have revolutionized the field of mass spectrometry over the past decade. However, many of these techniques require dedicated hardware and are often limited towards the detection of a specific class of compounds. The research reported in this dissertation focuses on the development and applications of multi-mode atmospheric ambient ionization source, which can be utilized towards the analysis of a wide range of compounds. The multi-mode ionization source can be operated under traditional electrospray ionization (ESI), atmospheric-pressure chemical ionization (APCI), and desorption electrospray ionization (DESI) modes, as well as the proprietary Stevens developed techniques desorption ionization by charge exchange (DICE) and helium plasma ionization (HePI). In the HePI technique, a non-thermal micro-plasma, generated by passing helium through a metal capillary held at high voltage, is used to ionize volatile organic compounds. Fundamental studies on the impact of helium flow rate, capillary position and voltage, and desorption gas flow rate and temperature on plasma formation and analyte-ion formation are reported. Furthermore, detection of a variety of compounds, including peptides/proteins, polymers, and small- molecule nonpolar and polar analytes, is demonstrated.
520 $a Several specific applications using the multi-mode ionization source are also described. The HePI technique was used to detect the residue of explosives (DNT, DNAN, TNT, RDX, HMX, PETN, and CL-20) directly a variety sample surfaces (glass, steel, clothing, paper, plastic, and skin), volatile organic compounds (vanillin, cinnamaldehyde, eugenol, pinene, limonene, carvone, and menthone) directly from foods and fragrances (ice cream, chewing gum, essential oils), and active pharmaceutical ingredients directly from commercial drug products. On the other hand, the ESI technique was employed towards the ionization of aminoglycoside antibiotics, organic sulfonic acids, COX-2 inhibitors, and hydroxybenzoic acids in an effort to develop a quantitative assay, investigate ion fragmentation mechanisms, examine distonic radical ion-molecule reactions, and probe the impact of solvent on ESI ion formation, respectively.
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