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Development of safe and efficacious ...

Dahal, Neeti.

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Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish./
作者:	Dahal, Neeti.
面頁冊數:	115 p.
附註:	Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.
Contained By:	Dissertation Abstracts International74-08B(E).
標題:	Veterinary science. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3558942
ISBN:	9781303037443

Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish.
Dahal, Neeti.

Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish. - 115 p.

Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.

Thesis (Ph.D.)--Mississippi State University, 2013.

This item is not available from ProQuest Dissertations & Theses.

Edwardsiella ictaluri is the causative agent of enteric septicemia of catfish (ESC), which is the most economically important disease of farm-raised channel catfish. E. ictaluri is considered a facultative intracellular pathogen like other well-known species in the Enterobacteriaceae, and it is capable of surviving inside channel catfish neutrophils and macrophages. Its ability to survive inside neutrophils and macrophages has made the development of an effective vaccine against ESC particularly challenging. The goal is to develop a safe, efficacious live attenuated ESC vaccine that is practical and economically beneficial to catfish producers.

ISBN: 9781303037443Subjects--Topical Terms:

3172798
Veterinary science.

Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish.
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245 1 0 $a Development of safe and efficacious live attenuated Edwardsiella ictaluri vaccines against enteric septicemia of catfish.
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500 $a Source: Dissertation Abstracts International, Volume: 74-08(E), Section: B.
500 $a Adviser: Mark L. Lawrence.
502 $a Thesis (Ph.D.)--Mississippi State University, 2013.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Edwardsiella ictaluri is the causative agent of enteric septicemia of catfish (ESC), which is the most economically important disease of farm-raised channel catfish. E. ictaluri is considered a facultative intracellular pathogen like other well-known species in the Enterobacteriaceae, and it is capable of surviving inside channel catfish neutrophils and macrophages. Its ability to survive inside neutrophils and macrophages has made the development of an effective vaccine against ESC particularly challenging. The goal is to develop a safe, efficacious live attenuated ESC vaccine that is practical and economically beneficial to catfish producers.
520 $a In this study, single and combination of mutations in genes encoding TCA cycle enzyme and C-1 metabolism proteins were constructed using in-frame mutagenesis. The virulence, vaccine efficacy, and tissue persistence of the constructed single and combination mutants were determined in channel catfish. The constructed mutants EideltasdhC, Eideltamdh, EideltafrdA , EideltaglyA, Eidelta sdhCdeltamdh, EideltasdhC deltafrdA, and Eidelta sdhCdeltagcvP were significantly attenuated and showed 100% protection against E. ictaluri 93-146 infection in juvenile channel catfish. However, when tested in 15-d old catfish fry, mutant EideltasdhCdeltagcvP and EideltafrdA were found to provide good protection (99% and 60%, respectively) against E. ictaluri 93-146 infection. The tissue persistence study indicated higher tissue concentration in mutants EideltasdhCdeltagcvP and EideltafrdA relative to the tissue concentration in EideltasdhC and EideltasdhCdeltafrdA mutants.
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