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Mechanisms of pre-mRNA splicing in y...

Hadjivassiliou, Haralambos A.

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Mechanisms of pre-mRNA splicing in yeast.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Mechanisms of pre-mRNA splicing in yeast./
作者:	Hadjivassiliou, Haralambos A.
面頁冊數:	117 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
Contained By:	Dissertation Abstracts International76-03B(E).
標題:	Biochemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3642673
ISBN:	9781321297072

Mechanisms of pre-mRNA splicing in yeast.
Hadjivassiliou, Haralambos A.

Mechanisms of pre-mRNA splicing in yeast. - 117 p.

Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2014.

This item must not be sold to any third party vendors.

The spliceosome is one of the cells largest and important molecular machines and yet it remains as one the least understood systems. This is a result of many experimentally challenging features inherent to the biology of splicing. In addition to having the largest number of unique proteins and RNAs associated with one process, the spliceosome has a complex assembly process that is both conformationally and compositionally dynamic. Classical genetics, much of it done in the Guthrie lab, revealed which proteins and RNAs were required for the process of splicing, but the molecular details of their interactions is still relatively unknown. In the past 10 years new biochemical tools have been developed, such as smFRET and metal substitution studies, which have increased our abilities to probe the structure and activity of the spliceosome. These techniques and others outlined in this proposal will be the foundation for the next ten years of research on the spliceosome. I believe that through these efforts and building on recent breakthroughs, the molecular mechanism of pre-mRNA splicing will be determined. These are truly exciting times to be studying the spliceosome.

ISBN: 9781321297072Subjects--Topical Terms:

518028
Biochemistry.

Mechanisms of pre-mRNA splicing in yeast.
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500 $a Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
500 $a Adviser: Christine Guthrie.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a The spliceosome is one of the cells largest and important molecular machines and yet it remains as one the least understood systems. This is a result of many experimentally challenging features inherent to the biology of splicing. In addition to having the largest number of unique proteins and RNAs associated with one process, the spliceosome has a complex assembly process that is both conformationally and compositionally dynamic. Classical genetics, much of it done in the Guthrie lab, revealed which proteins and RNAs were required for the process of splicing, but the molecular details of their interactions is still relatively unknown. In the past 10 years new biochemical tools have been developed, such as smFRET and metal substitution studies, which have increased our abilities to probe the structure and activity of the spliceosome. These techniques and others outlined in this proposal will be the foundation for the next ten years of research on the spliceosome. I believe that through these efforts and building on recent breakthroughs, the molecular mechanism of pre-mRNA splicing will be determined. These are truly exciting times to be studying the spliceosome.
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