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Intracranial occlusive arterial dise...

Li, Huan.

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Intracranial occlusive arterial disease in Chinese stroke patients.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Intracranial occlusive arterial disease in Chinese stroke patients./
作者:	Li, Huan.
面頁冊數:	320 p.
附註:	Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 3965.
Contained By:	Dissertation Abstracts International62-09B.
標題:	Medicine. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3025892
ISBN:	9780493378862

Intracranial occlusive arterial disease in Chinese stroke patients.
Li, Huan.

Intracranial occlusive arterial disease in Chinese stroke patients. - 320 p.

Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 3965.

Thesis (Ph.D.)--The Chinese University of Hong Kong (Hong Kong), 2001.

This item must not be sold to any third party vendors.

The Chinese population consecutive patients admitted with acute cerebral ischemia were included. Pre-stroke disability (modified Rankin scale, MRS) and severity of index stroke (National Institute of Health Stroke Scale, NIHSS) were assessed at the acute phase. Stroke subtype was classified according to the Oxfordshire Community Stroke Project (OCSP) classification. Cerebral vasculature was evaluated with transcranial Doppler ultrasonography (TCD). Patients documented with symptomatic middle cerebral artery (MCA) occlusive disease were reexamined by TCD after 6 months. Clinical outcome such as death and a further vascular event (stroke recurrence or acute coronary syndrome) were recorded at 6 months after stroke and during a long-term follow-up. Functional condition was also assessed meanwhile by use of Barthel Index BI.

ISBN: 9780493378862Subjects--Topical Terms:

641104
Medicine.

Intracranial occlusive arterial disease in Chinese stroke patients.
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100 1 $a Li, Huan. $3 3172172
245 1 0 $a Intracranial occlusive arterial disease in Chinese stroke patients.
300 $a 320 p.
500 $a Source: Dissertation Abstracts International, Volume: 62-09, Section: B, page: 3965.
500 $a Advisers: Richard L. C. Kay; Lawrence K. S. Wong.
502 $a Thesis (Ph.D.)--The Chinese University of Hong Kong (Hong Kong), 2001.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a The Chinese population consecutive patients admitted with acute cerebral ischemia were included. Pre-stroke disability (modified Rankin scale, MRS) and severity of index stroke (National Institute of Health Stroke Scale, NIHSS) were assessed at the acute phase. Stroke subtype was classified according to the Oxfordshire Community Stroke Project (OCSP) classification. Cerebral vasculature was evaluated with transcranial Doppler ultrasonography (TCD). Patients documented with symptomatic middle cerebral artery (MCA) occlusive disease were reexamined by TCD after 6 months. Clinical outcome such as death and a further vascular event (stroke recurrence or acute coronary syndrome) were recorded at 6 months after stroke and during a long-term follow-up. Functional condition was also assessed meanwhile by use of Barthel Index BI.
520 $a A total of 705 patients were included prospectively. Cerebral arterial occlusive lesions were identified ultrasonographically in 345 patients (49%), of whom 95% were identified with intracranial lesions, extracranial carotid lesion only accounted for 5%. Majority of patients (70%) had multiple lesions. At 6 months, 98 patients died or suffered a further vascular event, and 513 patients (73%) had a favorable functional recovery (BI scores > 80).
520 $a During a mean period of 25 months follow-up, 117 patients (17%) died and 199 (28%) suffered a further vascular event. Four hundred and fifty-six patients (65%) had a favorably functional outcome. Patients with vascular lesions had a poorer clinical outcome than those without. The number of vascular lesions remained a significant predictor for long-term clinical outcome [hazards ratio (HR) 1.17], as well as age (HR 1.03), diabetes (HR 1.33), and atrial fibrillation (HR 2.69). Further vascular event was strongly associated with long-term functional outcome (OR 3.11). Other predictors included age and NIHSS scores.
520 $a Six hundred and ninty-nine of 705 patients were classified with OCSP classification on admission. No difference of distribution of intracranial large artery abnormalities was found among OCSP stroke subtypes, but such stroke subtype was related to 6-month functional outcome. Patients with total anterior circulation infarct had the worst outcome.
520 $a Conclusions. Intracranial occlusive arterial disease is predominant in Chinese stroke patients. MCA is the most common lesion, progression of which could be a marker of clinical outcome. Presence and extent of intracranial occlusive arterial disease can predict early and long-term mortality and further vascular event. Lessening brain impairment of index stroke and secondary prevention of further vascular event could be benefit for early and long-term functional outcome.
590 $a School code: 1307.
650 4 $a Medicine. $3 641104
690 $a 0564
710 2 $a The Chinese University of Hong Kong (Hong Kong). $3 1017547
773 0 $t Dissertation Abstracts International $g 62-09B.
790 $a 1307
791 $a Ph.D.
792 $a 2001
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3025892