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Flexible Microimplants for In Vivo S...

Zhao, Yu.

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Flexible Microimplants for In Vivo Sensing.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Flexible Microimplants for In Vivo Sensing./
Author:	Zhao, Yu.
Description:	133 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
Contained By:	Dissertation Abstracts International76-03B(E).
Subject:	Engineering, Biomedical. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3643478
ISBN:	9781321311433

Flexible Microimplants for In Vivo Sensing.
Zhao, Yu.

Flexible Microimplants for In Vivo Sensing. - 133 p.

Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.

Thesis (Ph.D.)--California Institute of Technology, 2014.

This item must not be sold to any third party vendors.

The work in this thesis develops two types of microimplants for the application of cardiovascular in vivo biomedical sensing, one for short-term diagnosis and the other for long-term monitoring.

ISBN: 9781321311433Subjects--Topical Terms:

1017684
Engineering, Biomedical.

Flexible Microimplants for In Vivo Sensing.
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020 $a 9781321311433
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100 1 $a Zhao, Yu. $3 1277443
245 1 0 $a Flexible Microimplants for In Vivo Sensing.
300 $a 133 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
500 $a Adviser: Yu-chong Tai.
502 $a Thesis (Ph.D.)--California Institute of Technology, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a The work in this thesis develops two types of microimplants for the application of cardiovascular in vivo biomedical sensing, one for short-term diagnosis and the other for long-term monitoring.
520 $a Despite advances in diagnosis and therapy, atherosclerotic cardiovascular disease remains the leading cause of morbidity and mortality in the Western world. Predicting metabolically active atherosclerotic plaques has remained an unmet clinical need. A stretchable impedance sensor manifested as a pair of quasi-concentric microelectrodes was developed to detect unstable intravascular. By integrating the impedance sensor with a cardiac catheter, high-resolution Electrochemical Impedance Spectroscopy (EIS) measurements can be conducted during cardiac catheterization. An inflatable silicone balloon is added to the sensor to secure a well-controlled contact with the plaque under test in vivo. By deploying the device to the explants of NZW rabbit aorta and live animals, distinct EIS measurements were observed for unstable atherosclerotic plaques that harbored active lipids and inflammatory cells.
520 $a On the other hand, zebrafish (Danio rerio) is an emerging genetic model for heart regenerative medicine. In humans, myocardial infarction results in the irreversible loss of cardiomyocytes. Zebrafish hearts can fully regenerate after two months with 20% ventricular resection. Long-term electrocardiogram (ECG) recording can characterize the heart regeneration in a functional dimension. A flexible microelectrode membrane was developed to be percutaneously implanted onto a zebrafish heart and record epicardial ECG signals from specific regions on it. Region-specific aberrant cardiac signals were obtained from injured and regenerated hearts. Following that, in order to achieve continuous and wireless recording from non-sedated and non-restricted small animal models, a wireless ECG recording system was designed for the microelectrode membrane, prototyped on a printed circuit board and demonstrated on a one-day-old neonatal mouse. Furthermore, a flexible and compact parylene C printed circuit membrane was used as the integration platform for the wireless ECG recording electronics. A substantially miniature wireless ECG recording system was achieved.
590 $a School code: 0037.
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Electronics and Electrical. $3 626636
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690 $a 0544
710 2 $a California Institute of Technology. $b Electrical Engineering. $3 2093069
773 0 $t Dissertation Abstracts International $g 76-03B(E).
790 $a 0037
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3643478