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Alterations of NMDA and GABAB recept...

Bolton, Monica Michelle.

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Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia./
Author:	Bolton, Monica Michelle.
Description:	113 p.
Notes:	Source: Masters Abstracts International, Volume: 52-03.
Contained By:	Masters Abstracts International52-03(E).
Subject:	Biology, Neuroscience. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1546850
ISBN:	9781303471797

Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia.
Bolton, Monica Michelle.

Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia. - 113 p.

Source: Masters Abstracts International, Volume: 52-03.

Thesis (M.A.)--University of Nevada, Las Vegas, 2013.

Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated by glutamate via NMDA receptors are important for oscillatory activity involved with sensory processing and cognitive function. Alterations in the function of NMDA receptors on GABAeric interneurons are implicated in regulating neural network activity and, if disrupted, could potentially lead to altered brain function and deficits seen in schizophrenia. Several investigations have demonstrated reduction in NMDA receptor function or GABA receptor function induces deficits consistent with schizophrenia. Recent approaches have also focused on changes in NMDA or GABA function related to schizophrenia as a neurodevelopmental disorder. This approach suggests that alterations in either system during brain development may result in behavioral deficits later in life. The purpose of the below studies was to determine if changes in NMDA receptor function or alterations in downstream GABA receptor function during development in rodent pups results in behavioral or biochemical alterations in adulthood that are relevant to schizophrenia. The data reveal that altering these receptor systems in development produce deficits in adulthood. Changes in sensorimotor gating, spatial learning and memory, and differential expression of multiple GABA related proteins in the brain tissue were observed in these animals.

ISBN: 9781303471797Subjects--Topical Terms:

1017680
Biology, Neuroscience.

Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia.
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100 1 $a Bolton, Monica Michelle. $3 3168753
245 1 0 $a Alterations of NMDA and GABAB receptor function in development: A potential animal model of schizophrenia.
300 $a 113 p.
500 $a Source: Masters Abstracts International, Volume: 52-03.
500 $a Adviser: Jefferson Kinney.
502 $a Thesis (M.A.)--University of Nevada, Las Vegas, 2013.
520 $a Schizophrenia is a debilitating mental disorder that affects up to 3% of the world population. The behavioral symptoms are categorized into positive and negative symptoms, which appear during late adolescence/early adulthood. Unfortunately, the underlying cellular and molecular mechanisms of the disease are poorly understood. Several hypotheses exist to explain mechanisms contributing to these behavioral alterations. One model proposes that a reduced function of the NMDA glutamate receptor on specific GABAergic interneurons may be responsible for deficits in schizophrenia. Post-mortem investigations provide evidence of reductions in both glutamate and GABA-related proteins in patients with schizophrenia. Further, GABAergic interneurons that are activated by glutamate via NMDA receptors are important for oscillatory activity involved with sensory processing and cognitive function. Alterations in the function of NMDA receptors on GABAeric interneurons are implicated in regulating neural network activity and, if disrupted, could potentially lead to altered brain function and deficits seen in schizophrenia. Several investigations have demonstrated reduction in NMDA receptor function or GABA receptor function induces deficits consistent with schizophrenia. Recent approaches have also focused on changes in NMDA or GABA function related to schizophrenia as a neurodevelopmental disorder. This approach suggests that alterations in either system during brain development may result in behavioral deficits later in life. The purpose of the below studies was to determine if changes in NMDA receptor function or alterations in downstream GABA receptor function during development in rodent pups results in behavioral or biochemical alterations in adulthood that are relevant to schizophrenia. The data reveal that altering these receptor systems in development produce deficits in adulthood. Changes in sensorimotor gating, spatial learning and memory, and differential expression of multiple GABA related proteins in the brain tissue were observed in these animals.
590 $a School code: 0506.
650 4 $a Biology, Neuroscience. $3 1017680
650 4 $a Psychology, Psychobiology. $3 1017821
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710 2 $a University of Nevada, Las Vegas. $b Psychology. $3 1681760
773 0 $t Masters Abstracts International $g 52-03(E).
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793 $a English
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