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Interleukin-27 = biological properti...

Jankowski, Marek.

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Interleukin-27 = biological properties and clinical application /

Record Type:	Electronic resources : Monograph/item
Title/Author:	Interleukin-27/ by Marek Jankowski, Tomasz Wandtke.
Reminder of title:	biological properties and clinical application /
Author:	Jankowski, Marek.
other author:	Wandtke, Tomasz.
Published:	Cham :Springer International Publishing : : 2016.,
Description:	vi, 86 p. :ill., digital ;24 cm.
[NT 15003449]:	IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.
Contained By:	Springer eBooks
Subject:	Interleukins. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-39664-4
ISBN:	9783319396644

Interleukin-27 = biological properties and clinical application /
Jankowski, Marek.

Interleukin-27biological properties and clinical application /[electronic resource] :by Marek Jankowski, Tomasz Wandtke. - Cham :Springer International Publishing :2016. - vi, 86 p. :ill., digital ;24 cm. - SpringerBriefs in immunology,2194-2773. - SpringerBriefs in immunology..

IL-27: Structure, Regulation and Variability -- IL-27: A Key Player in Immune Regulation -- IL-27 in Health and Disease.

This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.

ISBN: 9783319396644

Standard No.: 10.1007/978-3-319-39664-4doiSubjects--Topical Terms:

2194691
Interleukins.

LC Class. No.: QR185.8.I56

Dewey Class. No.: 571.96

Interleukin-27 = biological properties and clinical application /
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520 $a This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike.
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