東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

A Role for TP63 in Breast Cancer Ini...

Hutchinson, Justine Anne Ryland.

FindBook

Google Book

Amazon

博客來

A Role for TP63 in Breast Cancer Initiation.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	A Role for TP63 in Breast Cancer Initiation./
作者:	Hutchinson, Justine Anne Ryland.
面頁冊數:	208 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.
Contained By:	Dissertation Abstracts International75-06B(E).
標題:	Health Sciences, Pharmacology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3613698
ISBN:	9781303770524

A Role for TP63 in Breast Cancer Initiation.
Hutchinson, Justine Anne Ryland.

A Role for TP63 in Breast Cancer Initiation. - 208 p.

Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.

Thesis (Ph.D.)--Dartmouth College, 2013.

Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying metastasis or recurrence and therefore, more effective treatment strategies. The DeltaNp63alpha product of the TP63 gene is implicated in the self-renewal of normal epithelial stem cells, but its role in oncogenesis and in tumor stem cells remains poorly understood. We hypothesized that presence of DeltaNp63alpha modifies the activity of classical oncogenes within the mammary epithelial hierarchy. To test this hypothesis, we performed studies in two non-transformed mammary epithelial cell lines, as well as in a combination of established and novel transgenic mouse models. We isolated and manipulated the DeltaNp63alpha-expressing Lin-CD29highCD24 + stem cell enriched populations from the established MMTVAMYC mouse model of human breast cancer. We observed that DeltaNp63alpha increases proliferative capacity in the IMEC and HMEC mammary epithelial cell culture models, including the opposition the negative effects of Ras on proliferative capacity. Ectopic DeltaNp63alpha overlapped somewhat in function with ectopic MYC and loss of P53. We generated two transgenic mouse models, DeltaNp63AeGFP/Cre and hCK14pA eGFP/Cre, in an effort to target oncogene expression to the DeltaNp63alpha-expressing cells of the mammary epithelium. The clinical implications of this work are that targeting DeltaNp63alpha may be particularly effective in the early stages of oncogenesis, before lesions in multiple oncogene and tumor suppressor pathways have accumulated.

ISBN: 9781303770524Subjects--Topical Terms:

1017717
Health Sciences, Pharmacology.

A Role for TP63 in Breast Cancer Initiation.
LDR:02560nam a2200289 4500 001 1969065
005 20141219110826.5
008 150210s2013 ||||||||||||||||| ||eng d
020 $a 9781303770524
035 $a (MiAaPQ)AAI3613698
035 $a AAI3613698
040 $a MiAaPQ $c MiAaPQ
100 1 $a Hutchinson, Justine Anne Ryland. $3 2106323
245 1 2 $a A Role for TP63 in Breast Cancer Initiation.
300 $a 208 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.
500 $a Adviser: James DiRenzo.
502 $a Thesis (Ph.D.)--Dartmouth College, 2013.
520 $a Despite the availability of targeted therapies, breast cancer metastasis and recurrence remain clinically challenging problems. Understanding the function of stem cells in this disease may lead to identification of genetic pathways underlying metastasis or recurrence and therefore, more effective treatment strategies. The DeltaNp63alpha product of the TP63 gene is implicated in the self-renewal of normal epithelial stem cells, but its role in oncogenesis and in tumor stem cells remains poorly understood. We hypothesized that presence of DeltaNp63alpha modifies the activity of classical oncogenes within the mammary epithelial hierarchy. To test this hypothesis, we performed studies in two non-transformed mammary epithelial cell lines, as well as in a combination of established and novel transgenic mouse models. We isolated and manipulated the DeltaNp63alpha-expressing Lin-CD29highCD24 + stem cell enriched populations from the established MMTVAMYC mouse model of human breast cancer. We observed that DeltaNp63alpha increases proliferative capacity in the IMEC and HMEC mammary epithelial cell culture models, including the opposition the negative effects of Ras on proliferative capacity. Ectopic DeltaNp63alpha overlapped somewhat in function with ectopic MYC and loss of P53. We generated two transgenic mouse models, DeltaNp63AeGFP/Cre and hCK14pA eGFP/Cre, in an effort to target oncogene expression to the DeltaNp63alpha-expressing cells of the mammary epithelium. The clinical implications of this work are that targeting DeltaNp63alpha may be particularly effective in the early stages of oncogenesis, before lesions in multiple oncogene and tumor suppressor pathways have accumulated.
590 $a School code: 0059.
650 4 $a Health Sciences, Pharmacology. $3 1017717
650 4 $a Health Sciences, Oncology. $3 1018566
650 4 $a Health Sciences, General. $3 1017817
690 $a 0419
690 $a 0992
690 $a 0566
710 2 $a Dartmouth College. $b Pharmacology and Toxicology. $3 1683875
773 0 $t Dissertation Abstracts International $g 75-06B(E).
790 $a 0059
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3613698