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Synthesis of new small-molecule libr...

Liu, Song.

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Synthesis of new small-molecule libraries based on natural products.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Synthesis of new small-molecule libraries based on natural products./
作者:	Liu, Song.
面頁冊數:	387 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
Contained By:	Dissertation Abstracts International75-01B(E).
標題:	Chemistry, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3595941
ISBN:	9781303423161

Synthesis of new small-molecule libraries based on natural products.
Liu, Song.

Synthesis of new small-molecule libraries based on natural products. - 387 p.

Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.

Thesis (Ph.D.)--The University of Chicago, 2013.

This dissertation describes the synthesis of 3 new small-molecule libraries based on natural products. The first library is based on the Corynanthe family of alkaloid natural products, featuring a Michael addition/cyclization/Pictet-Spengler strategy. The second library is based on the biosynthesis of Mitragynine Pseudoindoxyl and Pumiloside from Strictosidine. Chemo-selective transformations of the indole moiety in the library compounds have been achieved to mimic the biosynthetic process. The third library is based on the total synthesis of 3-Deoxyrosaranolide, in which a modular and parallel synthesis of 16- to 19-membered macrolides and their derivatives has been completed.

ISBN: 9781303423161Subjects--Topical Terms:

1021807
Chemistry, General.

Synthesis of new small-molecule libraries based on natural products.
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520 $a This dissertation describes the synthesis of 3 new small-molecule libraries based on natural products. The first library is based on the Corynanthe family of alkaloid natural products, featuring a Michael addition/cyclization/Pictet-Spengler strategy. The second library is based on the biosynthesis of Mitragynine Pseudoindoxyl and Pumiloside from Strictosidine. Chemo-selective transformations of the indole moiety in the library compounds have been achieved to mimic the biosynthetic process. The third library is based on the total synthesis of 3-Deoxyrosaranolide, in which a modular and parallel synthesis of 16- to 19-membered macrolides and their derivatives has been completed.
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