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Application of DNA arrays and develo...

Yuan, Yuan.

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Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.

紀錄類型:	書目-語言資料,印刷品 : Monograph/item
正題名/作者:	Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes./
作者:	Yuan, Yuan.
面頁冊數:	103 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-04(E), Section: B.
Contained By:	Dissertation Abstracts International75-04B(E).
標題:	Chemistry, General. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3607266
ISBN:	9781303647956

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.
Yuan, Yuan.

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes. - 103 p.

Source: Dissertation Abstracts International, Volume: 75-04(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2014.

Methodology development to identify proteins that interact with the genome at specific locations is critical as it is widely recognized that much of gene regulation is controlled by gene-specific protein-DNA interactions. Recent developments on high density DNA arrays and powerful high-throughput mass spectrometry platforms have made it possible to query biological systems at the genome and proteome levels. There are three parts to this dissertation 1) we integrate DNA arrays with microfluidic aptamer selection and next generation DNA sequencing for rapid and efficient aptamer characterization and screening; 2) we investigate sequence-specific DNA-protein interactions in vitro; 3) we develop new protocols to investigate sequence-specific DNA-protein interactions in vivo..

ISBN: 9781303647956Subjects--Topical Terms:

1021807
Chemistry, General.

Application of DNA arrays and development of sequence-specific capture of DNA/protein complexes.
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